Key result
Mitral TEER linked to a ~2-point improvement in MoCA score at 3 months in HF.
Why the study?
The specific patterns of cognitive decline and the effect of TMVR on cognitive impairment in patients with severe mitral regurgitation and high operative risk were not well described.
Cohort (n=72)
Single-blind
No
Answers are grounded in this paper and cite their sources.
TMVR may confer cognitive gains in HF with severe MR; hypothesis-generating and requires randomized trials before practice change.
Aims: Interventional transcatheter edge-to-edge mitral valve repair (TMVR) is an established treatment option for patients with severe mitral regurgitation (MR) and high operative risk. Cognitive impairment is one of the most common conditions among often extensive comorbidities in these patients. The specific patterns of cognitive decline and particularly the effect of TMVR are not well described. Thus, this study aimed to investigate into the impact of TMVR on cognitive impairment, exercise capacity, and quality of life. Methods: Cognitive function (executive, naming, memory, attention, language, abstraction, and orientation) was assessed with the standardized Montreal Cognitive Assessment test (MoCA; range between 0 and 30 points) before and 3 months after TMVR in 72 consecutive patients alongside echocardiographic examination and assessment of exercise capacity (six-minute walk test) as well as quality-of-life questionnaires (Minnesota living with heart failure questionnaire, MLHF-Q). Results: Patients’ median age was 81 [76.0; 84.5] years, 39.7% were female with a median EuroScore II of 4.4% [2.9; 7.7]. The assessment of cognitive function showed a significant improvement of the cumulative MoCA-Test result (from 22.0 [19.0; 24.5] to 24 [22.0; 26.0]; p < 0.001) with significant changes in the subcategories executive (p < 0.001), attention (p < 0.001), abstraction (p < 0.001), and memory (p < 0.001). In addition, quality of life (from 47.5 [25.0; 69.3] to 24.0 [12.0; 40.0]; p < 0.001) and exercise capacity (from 220.0 m [160.0; 320.0] to 280.0 m [200.0; 380.0]; p = 0.003) increased significantly 3 months after the TMVR procedure. Conclusions: TMVR leads to a significant improvement of cognitive function, exercise capacity, and quality of life in patients with chronic heart failure in 3 months follow up and again highlights the benefit of the evermore established TMVR procedure for patients with high operative risk.
No takes yet. Share an insight, caveat, or question.
Gerçek et al. (2022) conducted a cohort in Heart Failure with Mitral Regurgitation (n=72). Transcatheter edge-to-edge mitral valve repair (TMVR) vs. Baseline (before intervention) was evaluated on Montreal Cognitive Assessment (MoCA) test score (p=<0.001). Transcatheter edge-to-edge mitral valve repair significantly improved the median Montreal Cognitive Assessment score from 22.0 to 24.0 (p < 0.001) at 3 months in patients with heart failure.
Synapse has enriched 10 related papers. Consider them for comparative context: