Многофакторные Механизмы Диабетической Кардиомиопатии При Сахарном Диабете 2-Го Типа: Роль Метаболических, Воспалительных, Нейровегетативных И Микроциркуляторных Нарушений

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Type 2 diabetes mellitus and diabetic cardiomyopathy (n=218). Intervention: Diabetic cardiomyopathy vs. Type 2 diabetes without cardiomyopathy and healthy controls. Primary outcome: Evident cardiovascular autonomic neuropathy.

Q: What does this research mean for the field?

Diabetic cardiomyopathy in patients with type 2 diabetes develops through a multifactorial pathogenesis characterized by concurrent insulin resistance, systemic inflammation, autonomic neuropathy, and microvascular dysfunction. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Ф.А. Икрамова

doi:10.5281/zenodo.23285098

October 10, 2026Open Access

Многофакторные Механизмы Диабетической Кардиомиопатии При Сахарном Диабете 2-Го Типа: Роль Метаболических, Воспалительных, Нейровегетативных И Микроциркуляторных Нарушений

View Full Paper

Ask AI

Bookmark

Share

Key result

Diabetic cardiomyopathy in T2DM is linked to ~4-fold higher rates of cardiovascular autonomic neuropathy.

n=218

Why the study?

The study aimed to analyze the combination of metabolic, inflammatory, neurovegetative, and microcirculatory disturbances in patients with type 2 diabetes and diabetic cardiomyopathy to understand multifactorial mechanisms.

Are metabolic, inflammatory, neurovegetative, and microcirculatory disorders associated with diabetic cardiomyopathy in patients with type 2 diabetes?

Key Points

To evaluate the collective role of metabolic, inflammatory, autonomic, and microcirculatory disturbances in patients with type 2 diabetes presenting with diabetic cardiomyopathy.
Clinical and laboratory examination of 188 patients with type 2 diabetes (including 87 diagnosed with diabetic cardiomyopathy) and 30 control participants.
Assessment of carbohydrate metabolism (HOMA-IR), systemic inflammatory markers (hs-CRP, IL-6), heart rate variability metrics, and conjunctival microcirculation parameters.
Patients with cardiomyopathy exhibited pronounced insulin resistance (HOMA-IR: 9.34 ± 0.61 arbitrary units vs. 2.03 ± 0.14 in controls) alongside elevated inflammatory markers (hs-CRP: 6.18 ± 0.39 mg/L; IL-6: 9.74 ± 0.62 pg/mL).
Overt cardiovascular autonomic neuropathy occurred in 47.1% of patients with diabetic cardiomyopathy compared to 11.9% of type 2 diabetes patients without cardiomyopathy.
The total conjunctival index among cardiomyopathy patients was 13.9 ± 0.7 arbitrary units, representing a 4.3-fold increase over control levels.

Study Design

Type

Observational (n=218)

Structured PICO

Are metabolic, inflammatory, neurovegetative, and microcirculatory disorders associated with diabetic cardiomyopathy in patients with type 2 diabetes?

P

Population

218 individuals, comprising 188 patients with type 2 diabetes mellitus (87 with diabetic cardiomyopathy) and 30 control subjects, evaluated for multifactorial mechanisms of myocardial damage.

C

Comparator

Control group (individuals without diabetes) and patients with type 2 diabetes without cardiomyopathy

O

Outcome

Metabolic, inflammatory, neurovegetative, and microcirculatory markers (HOMA-IR, hs-CRP, IL-6, cardiovascular autonomic neuropathy, total conjunctival index)surrogate

Main Result

Absolute Event Rate: 47.1% vs 11.9%

Diabetic cardiomyopathy in type 2 diabetes is driven by a multifactorial interplay of insulin resistance, systemic inflammation, autonomic neuropathy, and microcirculatory dysfunction, rather than a single mechanism.

Implication

Higher autonomic neuropathy prevalence in T2DM with cardiomyopathy; hypothesis-generating for neurovegetative role, prospective studies needed before clinical implications.

Abstract

Цель — проанализировать сочетание метаболических, воспалительных, нейровегетативных и микроциркуляторных нарушений у пациентов с СД2 и диабетической кардиомиопатией. Материал и методы. Рассмотрены результаты обследования 188 пациентов с СД2 и 30 лиц контрольной группы; кардиомиопатия выявлена у 87 пациентов. Анализ основан на показателях углеводного обмена, маркерах воспаления, параметрах вариабельности сердечного ритма и оценке микроциркуляции, приведенных в автореферате. Результаты. В группе кардиомиопатии HOMA-IR составлял 9,34±0,61 усл. ед. против 2,03±0,14 в контроле; hs-CRP — 6,18±0,39 мг/л, IL-6 — 9,74±0,62 пг/мл. Явная кардиоваскулярная автономная нейропатия отмечалась у 47,1% пациентов против 11,9% в группе СД2 без кардиомиопатии. Общий конъюнктивальный индекс составлял 13,9±0,7 усл. ед. и был в 4,3 раза выше контрольного значения. Заключение. Совокупность данных поддерживает многофакторную модель диабетического поражения миокарда; ни один из рассмотренных механизмов не следует рассматривать как единственное объяснение ремоделирования сердца.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Ф.А. Икрамова (2026) conducted an observational in Type 2 diabetes mellitus and diabetic cardiomyopathy (n=218). Diabetic cardiomyopathy vs. Type 2 diabetes without cardiomyopathy and healthy controls was evaluated on Evident cardiovascular autonomic neuropathy. Diabetic cardiomyopathy in T2DM was associated with a higher prevalence of cardiovascular autonomic neuropathy compared to T2DM without cardiomyopathy (47.1% vs 11.9%).

synapsesocial.com/papers/6acc37c7d2063ff675899b60 https://doi.org/10.5281/zenodo.23285098

View Full Paper

Ask AI

Bookmark

Share

Key Points

Study Design

Structured PICO

Main Result

Implication

Abstract

Discussion

Cite This Study

Key Points

Study Design

Structured PICO

Main Result

Implication

Abstract

Discussion

Cite This Study

Keep reading

More related papers

Keep reading

More related papers