Key result
Early carotid atherosclerotic lesions localize to outer walls in a U-shaped pattern, sparing inner walls.
Why the study?
The detailed localization of early atherosclerotic lesions in the right carotid bifurcation was not well characterized in young humans.
Observational (n=37)
Maps early carotid lesion sites in young adults; hypothesis-generating for flow dynamics and requires prospective outcome validation.
The detailed localization of early atherosclerotic lesions in the right carotid bifurcation was studied in 37 carotid arteries obtained from autopsies of young persons who had suffered a violent and sudden death. Drawings of the sudanophilic lesions in the vessel wall were fed to a computer, scaled to a standardized size and shape, and added together. The results are presented as contour lines connecting points with equal frequency of early lesions. The distribution of early lesions reveals a distinct pattern: The early lesions start to develop on the outer walls of the bifurcation, while the inner walls downstream from the flow divider are left free, as are also the lateral walls. In the carotid sinus the distribution of the lesions has a U-formed pattern.
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Grøttum et al. (1983) conducted an observational in Early atherosclerotic lesions (n=37). Hemodynamic forces at the carotid bifurcation (anatomical exposure) vs. Inner walls downstream from the flow divider (internal control areas) was evaluated on Localization of sudanophilic early atherosclerotic lesions. Early atherosclerotic lesions in the right carotid bifurcation preferentially develop on the outer walls and form a U-shaped pattern in the carotid sinus, while sparing the inner walls downstream from the flow divider.
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