Key result
LOT-CRT produces marked T-wave inversions reflecting corrected ventricular activation.
Why the study?
Dramatic T-wave inversions after left bundle branch-optimized cardiac resynchronization therapy may indicate correction of altered ventricular activation sequence.
Following left bundle branch-optimized CRT, dramatic T-wave inversions on the ECG can serve as an indicator of corrected ventricular activation sequence.
T-wave inversions may mark restored activation after LBB-optimized CRT; hypothesis-generating and requires prospective validation before clinical use.
A 65-year-old man with dilated cardiomyopathy, a left ventricular ejection fraction of 25%, and left bundle branch block underwent left bundle branch-optimized cardiac resynchronization therapy. The post-procedure ECG showed dramatic T-wave inversions that often indicate correction of the altered ventricular activation sequence.
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Ishtiyaq Masood (2026) studied this question. Left bundle branch-optimized cardiac resynchronization therapy produced dramatic T-wave inversions indicating correction of the altered ventricular activation sequence.
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