Key result
High medication adherence linked to better quality of life across all domains in PAD.
Why the study?
Improving quality of life and achieving optimal medication adherence are important goals in the long-term pharmacotherapy of peripheral arterial disease, but their relationship is not well defined.
Does higher medication adherence improve health-related quality of life in patients with peripheral arterial disease?
Cohort (n=82)
Does higher medication adherence improve health-related quality of life in patients with peripheral arterial disease?
p-value: p=<0.001
Optimal medication adherence in patients with peripheral arterial disease is strongly correlated with improved health-related quality of life across all domains.
May support adherence counseling in PAD outpatients; leaves open whether interventions improve HRQoL.
Peripheral arterial disease (PAD) has a pronounced negative impact on an individual’s health-related quality of life (HRQoL). The pharmacotherapy of PAD involves long-term therapy. Improving the quality of life and achieving optimal adherence are important goals of PAD treatment. The aim was to examine the impact of therapeutic modalities and adherence on HRQoL in patients with PAD. This prospective study included 82 PAD patients treated on an outpatient basis. HRQoL was assessed using the Short Form 36 Health Survey (SF-36). After 6-month treatment, HRQoL was reassessed and adherence was assessed using the Adherence in Chronic Diseases Scale. Six months after therapy initiation, the SF-36 survey scores indicated improvement of HRQoL in study subjects. HRQoL improvement was observed in the group of respondents with a high degree of adherence (p<0.001). The results obtained showed that there was no statistically significant correlation between the choice of therapeutic modality and HRQoL, but indicated a statistically significant correlation between adherence and quality of life improvement in all domains (p<0.001). In conclusion, there was a significant correlation between the degree of adherence and HRQoL in patients with PAD.
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Damnjanović et al. (2026) conducted a cohort in Peripheral Arterial Disease (PAD) (n=82). Medication adherence was evaluated on Health-related quality of life (HRQoL) improvement assessed via SF-36 (p=<0.001). A high degree of medication adherence was significantly correlated with health-related quality of life improvement in all domains among patients with peripheral arterial disease (p<0.001).
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