Direct oral anticoagulants vs dual antiplatelet therapy after left atrial appendage occlusion: a meta-analysis of trials

“...our findings are most applicable to contemporary patients undergoing LAAO because of elevated bleeding risk and should be extrapolated cautiously to lower-risk populations," write Badran and Stone, noting that, given the relatively small size of the trials in the analysis, "larger trials are required to determine the optimal DOAC dose for this application.”