Key result
Successful chronic total occlusion (CTO) recanalization increased left ventricular ejection fraction by 4.44% (P<0.01) and reduced LV end-diastolic volume compared with baseline.
Why the study?
The clinical benefits of CTO interventions on left ventricular function and remodeling remain important due to frequent irreversible myocardial injury in CTO territories.
Meta-Analysis
Mean Difference: 4.44
p-value: p=<0.01
A meta-analysis by Hoebers et al. reported that successful chronic total occlusion (CTO) recanalization resulted in an increase in left ventricular (LV) ejection fraction by 4.44% (P<0.01) and a reduction in LV end-diastolic volume by 6.14 mL/m(2) during follow-up as compared with baseline, suggesting beneficial LV remodeling. These findings are important as the myocardium supplied by a CTO frequently has sustained irreversible injury and further support the clinical benefits of CTO interventions.
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Christakopoulos et al. (2015) conducted a meta-analysis in Chronic total occlusion (CTO). Successful chronic total occlusion (CTO) recanalization vs. Baseline was evaluated on Left ventricular (LV) ejection fraction (MD 4.44%, p=<0.01). Successful chronic total occlusion (CTO) recanalization increased left ventricular ejection fraction by 4.44% (P<0.01) and reduced LV end-diastolic volume compared with baseline.
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