Key result
Aging links to cardiomyocyte senescence and fibrosis, driving structural age-related cardiac dysfunction.
Why the study?
Morphological and histological changes in cardiac tissue during aging and their pathophysiological significance require systematic analysis.
Age-related cardiac dysfunction is driven by specific morphological changes, including cardiomyocyte senescence, interstitial fibrosis, and vascular degeneration.
Relevance. This review summarizes morphological and histological changes in cardiac tissue during aging, including cardiomyocyte hypertrophy and senescence, fibrosis, vascular change, conduction-system degeneration, fatty infiltration, and calcification. Objective. To analyze current evidence and its pathophysiological significance. Methods. Domestic and international publications on morphological and molecular aspects of myocardial aging were systematically analyzed. Results. Aging is associated with cardiomyocyte senescence, interstitial fibrosis, reduced capillary density, vascular and conduction-system degeneration, chronic inflammation, and oxidative stress. Conclusion. These changes form the morphological basis of age-related cardiac dysfunction.
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Chonkoev et al. (2026) conducted a review in Myocardial aging. Aging was evaluated on Morphological and histological changes in cardiac tissue. Aging is associated with cardiomyocyte senescence, interstitial fibrosis, and structural changes that form the morphological basis of age-related cardiac dysfunction.
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