Key result
CNS lymphoma presents with giant T-wave inversions and rapidly evolving echocardiographic changes mimicking acute coronary syndrome.
Why the study?
Giant T-wave inversions are a rare ECG finding typically linked to acute intracranial pathology, but their occurrence with subacutely growing intracerebral neoplastic lesions and evolving echocardiographic abnormalities is uncommon and diagnostically challenging.
Case Report (n=1)
Highlights that giant T-wave inversions (cerebral T waves), typically associated with acute intracranial hemorrhage, can also occur with a subacute central nervous system lymphoma, presenting a diagnostic challenge when accompanied by echocardiographic abnormalities.
Answers are grounded in this paper and cite their sources.
Neurocardiogenic T-wave changes warrant consideration in CNS lymphoma; leaves open systematic ECG evaluation in non-hemorrhagic intracranial masses.
Giant T-wave inversions, also known as “cerebral T waves,” are a rare electrocardiogram (ECG) finding classically associated with acute intracranial pathology, particularly subarachnoid hemorrhage and hemorrhagic stroke. They are thought to reflect neurocardiogenic autonomic dysregulation and may occur in association with intracranial mass effect, although intracranial pressure is not always directly measured in clinical practice. Cerebral T waves are uncommon in the setting of a subacutely growing intracerebral neoplastic lesion, and the diagnostic challenge is amplified when they occur alongside rapidly evolving echocardiographic abnormalities.
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Baqal et al. (2026) conducted a case report in Central Nervous System Lymphoma (n=1). Central nervous system lymphoma with subacutely growing intracerebral neoplastic lesion was evaluated. Giant T-wave inversions and rapidly evolving echocardiographic abnormalities presented a diagnostic challenge in a patient with a subacutely growing central nervous system lymphoma.
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