Why the study?
The clinical effect of combined metoprolol and trimetazidine treatment in elderly patients with coronary heart disease and heart failure was unclear.
Does the combination of metoprolol and trimetazidine improve symptoms, cardiac function, and quality of life in elderly patients with heart failure due to coronary heart disease?
RCT (n=128)
Random number table
No
Does the combination of metoprolol and trimetazidine improve symptoms, cardiac function, and quality of life in elderly patients with heart failure due to coronary heart disease?
Mean Difference: 5.56
Absolute Event Rate: 42.34% vs 36.78%
p-value: p=0.000
Adding metoprolol and trimetazidine to standard heart failure therapy significantly accelerates symptom relief, improves echocardiographic parameters, and enhances quality of life in elderly patients with ischemic heart failure.
May support adjunctive metoprolol-trimetazidine in elderly CHD-HF; hypothesis-generating and requires larger RCTs before practice change.
姜 韬 ( 汉中市第二人民医院 ) 目的:探讨美托洛尔、曲美他嗪联合治疗老年冠心病心力衰竭的临床效果。方法:选取2022年3月至 2025年9月在我院心内科住院治疗的老年冠心病心力衰竭患者128例,采用随机数字表法分为观察组和对照组各64例。 对照组给予常规治疗,观察组在对照组基础上加用美托洛尔、曲美他嗪联合治疗。比较两组患者的临床疗效指标、心 功能指标及生活质量评分。结果:观察组临床疗效指标改善程度优于对照组;心功能指标显著改善;生活质量评分明 显提高。观察组各项观察指标均优于对照组(p < 0.05)。结论:美托洛尔、曲美他嗪联合治疗老年冠心病心力衰竭 效果显著,值得临床推广应用。 目的:探讨美托洛尔、曲美他嗪联合治疗老年冠心病心力衰竭的临床效果。方法:选取2022年3月至 2025年9月在我院心内科住院治疗的老年冠心病心力衰竭患者128例,采用随机数字表法分为观察组和对照组各64例。 对照组给予常规治疗,观察组在对照组基础上加用美托洛尔、曲美他嗪联合治疗。比较两组患者的临床疗效指标、心 功能指标及生活质量评分。结果:观察组临床疗效指标改善程度优于对照组;心功能指标显著改善;生活质量评分明 显提高。观察组各项观察指标均优于对照组(p < 0.05)。结论:美托洛尔、曲美他嗪联合治疗老年冠心病心力衰竭 效果显著,值得临床推广应用。
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韬 姜 (2026) conducted an RCT in Coronary heart disease with heart failure (n=128). Metoprolol and Trimetazidine vs. Conventional therapy (nitrates, ACE inhibitors, diuretics) was evaluated on Left ventricular ejection fraction (LVEF) (p=0.000).
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