Key result
Hypothermia plus cord blood cells lowers systolic blood pressure by ~21 mmHg in hypertensive rats.
Why the study?
The relationship between arterial hypertension and autonomic nervous system imbalance and the effects of craniocerebral hypothermia and nucleated cord blood cells on autonomic regulation were investigated.
Does combined rhythmic craniocerebral hypothermia and nucleated cord blood cell administration improve autonomic nervous system balance and reduce blood pressure in a spontaneously hypertensive rat model?
Does combined rhythmic craniocerebral hypothermia and nucleated cord blood cell administration improve autonomic nervous system balance and reduce blood pressure in a spontaneously hypertensive rat model?
Combined craniocerebral hypothermia and nucleated cord blood cell therapy synergistically restored autonomic sympathovagal balance and produced sustained reductions in arterial blood pressure in hypertensive rats.
Does not support clinical use in hypertension; leaves open translation of combined rhythmic craniocerebral hypothermia and nucleated cord blood cells to human trials.
This study investigated the effects of rhythmic craniocerebral hypothermia (rCCH), administration of cryopreserved nucleated cord blood cells (NCBCs), and their combined application on autonomic regulation of heart rate and arterial blood pressure (BP) parameters in 12 month old spontaneously hypertensive rats (SHRs) with arterial hypertension (AH). A relationship was established between AH and autonomic nervous system imbalance. SHRs demonstrated a shift in heart rate variability (HRV) indices toward enhanced sympathetic activity, which may indicate reduced neurohumoral regulation and signs of overstrain and asthenization within central regulatory structures. On day 7 after the combined application of rCCH and NCBCs, the adaptive compensatory capacity of the organism increased signifi cantly. Although these effects diminished by day 30, they remained higher compared to the use of each method separately. In addition, unlike the independent application of rCCH or NCBCs, their combined use resulted in a reduction of both systolic and diastolic BP.
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Lomakin et al. (2026) studied Arterial hypertension (n=40). Rhythmic craniocerebral hypothermia and nucleated cord blood cells vs. Untreated SHR control, rCCH alone, and NCBCs alone was evaluated on Systolic blood pressure at day 30 (p=<0.05). Combined application of rhythmic craniocerebral hypothermia and nucleated cord blood cells significantly reduced systolic blood pressure from a baseline of 221.1 mmHg to 200.0 mmHg at day 30 in spontaneously hypertensive rats.
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