Key result
Cross-sectional study establishes normal native myocardial T1 reference values averaging ~998 ms on 1.5T CMR.
Why the study?
Absolute myocardial T1 and T2 relaxation times vary across imaging platforms due to system-specific technical factors, requiring scanner-specific calibration for accurate reference ranges.
What are the normal reference ranges for native myocardial T1 and T2 mapping on a 1.5T Siemens Aera system in a healthy South African population?
Cross-Sectional (n=76)
No
What are the normal reference ranges for native myocardial T1 and T2 mapping on a 1.5T Siemens Aera system in a healthy South African population?
This study establishes locally validated, scanner-specific normative reference ranges for native T1 and T2 mapping on a 1.5T Siemens Aera system for a South African population, enabling accurate clinical interpretation of quantitative myocardial tissue characteristics.
Answers are grounded in this paper and cite their sources.
Scanner-specific T1/T2 references now available for this system; extends platform-variability data to a South African cohort.
ackground: Quantitative myocardial T1 and T2 mapping is integral to cardiovascular magnetic resonance (CMR) imaging. Absolute myocardial relaxation times vary across imaging platforms due to system-specific technical factors. Consequently, mapping reference ranges are not transferable across platforms and require scanner-specific calibration. This study aimed to establish normal T1 and T2 reference intervals on a 1.5 Tesla (T) Siemens Aera system (Siemens, Erlangen, Germany) at Tygerberg Hospital. Methods: Healthy adults were prospectively enrolled using strict inclusion criteria. Participants were required to undergo a normal clinical evaluation before qualifying for CMR and potential study inclusion. Final inclusion followed confirmation of normal cardiac structure and function, with no late gadolinium enhancement (LGE) on CMR. CMR imaging included balanced steady-state free precession (SSFP) cine sequences, shortened modified Look-Locker inversion recovery (shMOLLI) T1 mapping, and T2-prepared mapping sequences with a balanced SSFP readout. Analysis was performed using cvi42 software (Circle Cardiovascular Imaging, Canada) with manual contouring, and reference ranges were derived as mean ± 2 standard deviations (SD). Results: A total of 76 participants met the inclusion criteria. Mean global native T1 was 998 ± 25.6 ms (reference interval 947–1 049 ms) and native T2 was 46.6 ± 1.8 ms (reference interval 43.0–50.1 ms). Conclusion: This study established scanner-specific native T1 and T2 reference intervals for a South African population scanned on a 1.5T Siemens Aera system.
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Louis Jonas Giliomee (2026) conducted a cross-sectional in Healthy adults (n=76). Native T1 and T2 cardiovascular magnetic resonance mapping was evaluated on Scanner-specific global native T1 and T2 reference intervals. In a healthy South African cohort, global native myocardial T1 and T2 relaxation times on a 1.5T Siemens Aera system averaged 998 ms and 46.6 ms, respectively, establishing scanner-specific reference intervals.
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