Successful Heart Transplantation in a Woman With LMNA‐Related Emery–Dreifuss Muscular Dystrophy: A Case Report and Literature Review

Introduction Emery–Dreifuss muscular dystrophy (EDMD) is a rare inherited neuromuscular disorder frequently associated with progressive cardiac involvement, particularly in patients carrying LMNA mutations. End‐stage heart failure may develop despite optimal medical and device therapy, although heart transplantation remains an uncommon therapeutic option because of concerns regarding the underlying neuromuscular disease. Case Presentation We report the case of a 35‐year‐old woman with LMNA ‐related EDMD who developed advanced biventricular heart failure complicated by recurrent atrial and ventricular arrhythmias, complete atrioventricular block, implantable cardioverter‐defibrillator implantation, and multiple thromboembolic events. Pretransplant neurological and respiratory assessments demonstrated preserved functional status without severe musculoskeletal impairment. Owing to refractory ventricular tachyarrhythmias and progressive heart failure, the patient underwent orthotopic heart transplantation in December 2022. Postoperative recovery was uneventful, with discharge on postoperative day 21. At 43‐month follow‐up, she remained alive with preserved graft function, no episodes of rejection, stable respiratory function, and no evidence of neurological deterioration. Conclusion Heart transplantation may be a feasible treatment option for carefully selected patients with EDMD and end‐stage heart failure. Careful multidisciplinary assessment is essential to identify candidates who can achieve favorable long‐term outcomes.