Takotsubo Cardiomyopathy in Myasthenia Gravis-emergency Recognition and Management of a Life-threatening Overlap: A Narrative Review

Takotsubo Cardiomyopathy (TTC), also known as stress cardiomyopathy or broken heart syndrome, is a condition where temporary left ventricular dysfunction occur. This often happens because of emotional or physical stress. Myasthenia Gravis (MG) is an autoimmune disorder that affects the neuromuscular junction, causing fluctuating muscle weakness. Co‑occurrence of these two conditions is rare. However, clinicians must distinguish between them, especially in an emergency. The present narrative review examines the unusual association between TTC and MG. This review focuses on rapid recognition in emergencies, the difficulties in diagnosing it, and how to manage this potentially fatal condition. The present review thoroughly examines existing literature, including case reports and systematic reviews. The authors examined articles discussing the co-occurrence of TTC and MG. The authors also examined their biological mechanisms, clinical presentation, diagnostic approaches, and treatment strategies. They thoroughly examined peer-reviewed journals from 2005 to 2025. The present analysis indicates that distinguishing between TTC and MG is difficult when both are present simultaneously. Key challenges include differentiating TTC from Myasthenic Crisis (MC) and determining the optimal management of acute cardiac complications in patients with MG. Providing supportive care and appropriate treatment is essential to helping patients recover from such emergencies. The discussion highlights the need to identify TTC early and to appropriately manage it in patients with MG, who are at risk of such emergencies. Other studies will strengthen clinical guidelines, empowering doctors to manage rare but deadly overlap disease cases more effectively.