Кардиоваскулярная Автономная Нейропатия При Сахарном Диабете 2 Типа: Клинико-Диагностический Анализ На Основе Тестов Юинга И Опросника Автономных Симптомов

Q: What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Type 2 diabetes mellitus (n=106). Intervention: HbA1c. Primary outcome: Severity of cardiovascular autonomic neuropathy (CAN) based on the number of abnormal Ewing tests (OR 0.860, 95% CI 0.751-0.986, p=0.031).

Q: What does this research mean for the field?

Cardiovascular autonomic neuropathy is highly prevalent (93.4%) in patients with type 2 diabetes, with HbA1c functioning as an independent predictor of severity (OR 0.860). Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Хайдарова Г.А.; Алиева А.В.; Тригулова Раиса Хусаиновна

doi:10.64156/mju.9700

January 1, 2026Medicinskij žurnal UzbekistanaOpen Access

Кардиоваскулярная Автономная Нейропатия При Сахарном Диабете 2 Типа: Клинико-Диагностический Анализ На Основе Тестов Юинга И Опросника Автономных Симптомов

View Full Paper

Ask AI

Bookmark

Share

Key result

Higher HbA1c linked to ~14% lower odds of severe cardiovascular autonomic neuropathy in T2D.

OR 0.860
95% CI 0.751-0.986
P=0.031
n=106

Why the study?

Cardiovascular autonomic neuropathy (CAN) is a frequent and prognostically unfavorable complication of type 2 diabetes mellitus (T2DM) with subclinical early stages leading to underdiagnosis in routine practice, necessitating active screening.

Key Points

To determine the frequency and severity of cardiovascular autonomic neuropathy in patients with type 2 diabetes mellitus using standard Ewing reflex tests and identify clinical determinants.
Conducted a single-center cross-sectional study in 106 consecutive patients with type 2 diabetes (60 men, 46 women; mean age 54.5±9.5 years; diabetes duration 7.4±4.5 years).
Administered five standard Ewing tests (deep breathing, Valsalva maneuver, 30:15 ratio, orthostatic test, isometric handgrip) staged by the 2011 Toronto Consensus criteria.
Abnormal results appeared in 92.1% on the Valsalva maneuver, 89.4% on isometric testing, 79.4% on deep breathing, and 20.8% had orthostatic hypotension.
Abnormal test counts correlated with diabetes duration (rs=0.34; p<0.001) and triglycerides (rs=0.22; p=0.028), with HbA1c predicting severity in multivariable ordinal logistic regression (OR=0.860; 95% CI 0.751–0.986; p=0.031).

Study Design

Type

Cross-Sectional (n=106)

Multicenter

No

Structured PICO

P

Population

106 adults (mean age 54.5 years) with type 2 diabetes were evaluated in a cross-sectional study to determine the prevalence and clinical determinants of cardiovascular autonomic neuropathy.

O

Outcome

Frequency and severity of cardiovascular autonomic neuropathy (CAN) based on five standard Ewing cardiovascular reflex tests (Toronto Consensus 2011 criteria) and clinical/laboratory determinants of CANsurrogate

Main Result

Odds Ratio: 0.86 (95% CI 0.751–0.986)

p-value: p=0.031

Cardiovascular autonomic neuropathy is an extremely common but largely subclinical complication in patients with poorly controlled type 2 diabetes, underscoring the importance of routine screening using Ewing's cardiovascular reflex tests.

Limitations

Cross-sectional design limits ability to establish causal relationships or temporal sequence.
Single-center hospital-based cohort may introduce selection bias toward more severe disease.
Use of fixed, non-age-adjusted thresholds for Ewing tests could lead to overdiagnosis in older patients.
Small comparison group without severe CAN (n=7) reduces statistical power for comparisons.
Lack of spectral heart rate variability analysis or MIBG scintigraphy to fully characterize sympathetic denervation.
Selection bias due to recruitment from a specialized endocrinology center (patients with long diabetes history, poor glycemic control, and multiple complications)
Use of fixed, non-age-adjusted thresholds for Ewing tests, potentially leading to overdiagnosis in older patients
Small sample size limiting statistical power for multivariable analysis
Cross-sectional design limiting causal inferences

Implication

May warrant CAN screening consideration in T2DM; leaves open whether HbA1c modification alters progression.

Abstract

КАРДИОВАСКУЛЯРНАЯ АВТОНОМНАЯ НЕЙРОПАТИЯ ПРИ САХАРНОМ ДИАБЕТЕ 2 ТИПА: КЛИНИКО-ДИАГНОСТИЧЕСКИЙ АНАЛИЗ НА ОСНОВЕ ТЕСТОВ ЮИНГА И ОПРОСНИКА АВТОНОМНЫХ СИМПТОМОВ Хайдарова Г.А.-докторант в Республиканской специализированной научнопрактической медицинского центре эндокринологии.E-mail: gavhar

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Г.А. et al. (2026) conducted a cross-sectional in Type 2 diabetes mellitus (n=106). HbA1c was evaluated on Severity of cardiovascular autonomic neuropathy (CAN) based on the number of abnormal Ewing tests (OR 0.860, 95% CI 0.751-0.986, p=0.031).

synapsesocial.com/papers/6ad0fd553afa093ea9ad03f6 https://doi.org/10.64156/mju.9700

View Full Paper

Ask AI

Bookmark

Share

Кардиоваскулярная Автономная Нейропатия При Сахарном Диабете 2 Типа: Клинико-Диагностический Анализ На Основе Тестов Юинга И Опросника Автономных Симптомов

Key Points

Study Design

Structured PICO

Main Result

Limitations

Implication

Abstract

Discussion

Cite This Study

Кардиоваскулярная Автономная Нейропатия При Сахарном Диабете 2 Типа: Клинико-Диагностический Анализ На Основе Тестов Юинга И Опросника Автономных Симптомов

Key Points

Study Design

Structured PICO

Main Result

Limitations

Implication

Abstract

Discussion

Cite This Study

Keep reading

More related papers

More from Medicinskij žurnal Uzbekistana

Keep reading

More related papers

More from Medicinskij žurnal Uzbekistana