Key result
Radiofrequency ablation to reduce premature ventricular complex burden can improve both systolic and diastolic function, reverse left ventricular remodeling, and enhance quality of life.
Why the study?
Frequent PVCs can impair left ventricular systolic function, but most patients with frequent PVCs do not develop cardiomyopathy, and predictors and mechanisms remain to be clarified.
Frequent PVCs can lead to cardiomyopathy, which may be unmasked by advanced imaging and genetics, and is potentially reversible with radiofrequency ablation.
Answers are grounded in this paper and cite their sources.
May support ablation consideration in PVC cardiomyopathy; leaves open need for RCTs to confirm selection and durability.
Frequent premature ventricular complexes (PVCs) are well known to impair left ventricular systolic function. However, most patients with frequent PVCs do not develop cardiomyopathy. We review the various predictors and mechanisms of PVCs that lead to cardiomyopathy, with an emphasis on right ventricular outflow tract PVC-induced left ventricular dyssynchrony and diastolic dysfunction. The variable myocardial susceptibility to PVCs may be due to an undiagnosed subclinical cardiomyopathy. Advanced imaging modalities and genetic screening may help identify primary cardiomyopathic processes. Radiofrequency ablation to reduce PVC burden can not only improve both systolic and diastolic function but also reverse left ventricular remodeling and enhance quality of life.
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Meili et al. (2026) conducted a review in Premature ventricular complex induced cardiomyopathy. Radiofrequency ablation was evaluated. Radiofrequency ablation to reduce premature ventricular complex burden can improve both systolic and diastolic function, reverse left ventricular remodeling, and enhance quality of life.
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