Key result
Losartan and magnesium supplementation protect against hypertension and salt-induced oxidative stress in rats.
Why the study?
Mg2+ deficiency is linked to oxidative stress, inflammation, and hypertension, and defective Mg2+ metabolism may contribute to hypertension in Dahl salt-sensitive rats.
Does Losartan and/or Mg2+ supplementation reduce hypertension and oxidative stress in male Dahl salt-sensitive rats fed a high-NaCl diet?
RCT
randomly assigned
Does Losartan and/or Mg2+ supplementation reduce hypertension and oxidative stress in male Dahl salt-sensitive rats fed a high-NaCl diet?
In salt-sensitive rats on a high-sodium diet, Losartan and magnesium supplementation mitigate hypertension and oxidative stress through distinct mechanisms involving RAAS attenuation and increased nitric oxide, respectively.
Mg²⁺ deficiency has been linked to oxidative stress, inflammation, and hypertension. We have previously shown that Losartan increases plasma Mg²⁺ levels in Dahl salt-sensitive (Dahl) rats, suggesting that defective Mg²⁺ metabolism in this strain contributes to hypertension. Here, we investigated the effects of dietary Mg²⁺ supplementation (0.3% MgO) and/or Losartan (10 mg/kg/day, in drinking water) in male Dahl rats fed a high-NaCl (8%) or standard Na⁺ diet for six weeks. Six-week-old rats were randomly assigned to eight experimental groups. NO metabolites (nitrites and nitrates) were measured in plasma and kidney homogenates. Oxidative stress was assessed by lipid peroxidation in plasma and red blood cell ghosts (RBCG), and by erythrocyte osmotic fragility (OS₅₀). Both Losartan and Mg²⁺ supplementation protected against hypertension and high-salt-induced systemic and local oxidative stress, with differential regulation of Na⁺/K⁺-ATPase and Na⁺-ATPase activity. A consistent "high Na⁺ effect" was observed across NaCl-fed groups, characterized by Renin-Angiotensin-Aldosterone System (RAAS) activation, increased Reactive Oxygen Species (ROS) production, lipid peroxidation, osmotic fragility, and elevated Na⁺/K⁺-ATPase activity. Losartan normalized blood pressure (BP) by attenuating renal RAAS activity and reducing oxidative stress, whereas Mg²⁺ supplementation increased (Nitrites + Nitrates) NO
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Rondón et al. (2026) conducted an RCT in Hypertension and oxidative stress. Losartan and/or Mg2+ supplementation vs. Standard Na+ diet / no treatment was evaluated on NO metabolites, lipid peroxidation, and erythrocyte osmotic fragility. Both Losartan and Mg2+ supplementation protected against hypertension and high-salt-induced systemic and local oxidative stress in male Dahl rats.
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