Key result
Intrauterine undernutrition links to adult hypertension, CAD, and diabetes via renal and vascular mechanisms.
Why the study?
Intrauterine undernutrition is hypothesized to be an important determinant of hypertension, coronary heart disease, and diabetes in adult offspring, but the renal and vascular mechanisms remain to be detailed.
Intrauterine undernutrition may program adult hypertension and metabolic disease; leaves open prospective human validation before any practice change.
OBJECTIVE: A large number of clinical and experimental studies supports the hypothesis that intrauterine undernutrition is an important determinant of hypertension, coronary heart disease and non-insulin-dependent diabetes in the adult offspring. In this review, the renal and vascular repercussions of maternal undernutrition are emphasized, and the physiopatologic mechanisms discussed. The origin of hypertension is detailed based upon the findings of kidney functional parameters and endothelium function studies. A working model linking hypertension to intrauterine undernutrition is proposed.
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Maria do Carmo Franco (2003) conducted a review in Hypertension, coronary heart disease, and non-insulin-dependent diabetes. Intrauterine undernutrition was evaluated on Hypertension, coronary heart disease and non-insulin-dependent diabetes in the adult offspring. Intrauterine undernutrition is proposed as an important determinant of hypertension, coronary heart disease, and non-insulin-dependent diabetes in adult offspring via renal and vascular mechanisms.
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