Key result
Higher serum talin1 is linked to ~67% higher odds of abnormal lipid metabolism.
Why the study?
The role of talin1 in lipid metabolism remains unclear in humans despite its implication in lipid-related biological processes in experimental studies.
Cross-Sectional (n=1,902)
No
Odds Ratio: 1.67 (95% CI 1.25–2.25)
p-value: p=0.001
Elevated serum talin1 levels are independently associated with hypercholesterolemic and atherogenic lipid metabolism states in adults free of cardiovascular disease, suggesting a potential role as a novel biomarker for preclinical lipid disturbances.
Talin1 may mark atherogenic dyslipidemia in community adults; hypothesis-generating and requires prospective validation before any clinical use.
Dyslipidemia is a major modifiable risk factor for atherosclerosis and cardiovascular disease. Talin1, a cytoskeletal protein essential for integrin activation, has been implicated in lipid-related biological processes in experimental studies. However, its role in lipid metabolism remains unclear in humans. Therefore, the aim of this study was to examine the association between serum talin1 levels and lipid metabolism in an unselected population of Chinese adults. A cross-sectional analysis of 1902 community members (mean age: 57.33 years; 37.85% males) free of cardiovascular disease was conducted. Serum talin1 levels were measured by a commercial ELISA, and nine indicators of lipid metabolism, namely, conventional cholesterol (TC, TG, LDL-C, and HDL-C) level, remnant cholesterol (RC) level, the triglyceride-glucose (TyG) index, the non-HDL-C level, the LDL-HDL ratio, and the plasma atherogenic index (AIP), were determined. The latent status of lipid metabolism was stratified by latent profile analysis incorporating these indicators. Median regression and logistic regression were applied to examine the associations of serum talin1 with lipid levels and metabolic status, respectively. Among the nine indicators, a higher level of serum talin1 was significantly associated with TC (β = 0.16, P = 0.010) and RC (β = 0.08, P < 0.001). A higher serum talin1 level was associated with a 67% greater risk of abnormal lipid metabolism, defined by elevated RC (OR = 1.67, 95%CI: 1.25–2.25, P = 0.001), rather than other indicators (all P > 0.05). Serum talin1 was significantly associated with adverse latent states of lipid metabolism, such as an atherogenic state (OR = 1.72, 95%CI: 1.11–2.30, P = 0.017) and a hypercholesterolemic state (OR = 1.63, 95%CI: 1.16–2.31, P = 0.005). Elevated serum talin1 levels were not only significantly associated with higher levels of TC and RC but also indicated adverse states of lipid metabolism, hypercholesterolemic and atherogenic states particularly, in an unselected population of Chinese adults.
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Meng et al. (2026) conducted a cross-sectional in Dyslipidemia / Abnormal lipid metabolism (n=1,902). Serum talin1 level vs. Lower serum talin1 levels (or continuous log-talin1) was evaluated on Abnormal lipid metabolism defined by elevated remnant cholesterol (OR 1.67, 95% CI 1.25-2.25, p=0.001). Higher serum talin1 levels were significantly associated with a 67% greater risk of abnormal lipid metabolism defined by elevated remnant cholesterol (OR 1.67).
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