Key result
Peripheral muscle abnormalities drive reduced exercise capacity in heart failure.
Why the study?
Reduced exercise tolerance in heart failure patients is mainly caused by peripheral factors including skeletal muscle alterations and decreased ATP production, but the linkage between mitochondrial function in heart and leg muscles is unclear.
Answers are grounded in this paper and cite their sources.
Heart failure (HF) is a chronic and devastating illness becoming an increasingly important burden on the health care system. Reduced exercise tolerance is an independent predictor of hospital readmission and mortality in patients with HF [1], and is thought to be a therapeutic target [2]. Although central factors such as ejection fraction (EF) or cardiac output do play a role, peripheral factors which include reduced skeletal muscle, an alteration in fiber type to one with less oxidative properties, and decreased ATP production, are mainly responsible for the reduction in exercise capacity [3].
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Kato et al. (2015) conducted a review in Heart failure. Peripheral factors including altered skeletal muscle fiber type and decreased ATP production are mainly responsible for the reduction in exercise capacity in patients with heart failure.
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