Key result
Severe aortic regurgitation is linked to significantly altered muscular aortic valve annular deformation vs controls.
Why the study?
It remains unclear what factors contribute to isolated cusp prolapse causing aortic regurgitation, and detailed tracking of AV annulus deformation was not possible with prior CT analyses.
Case-Control (n=11)
No
OBJECTIVES: We evaluated the potential of cardiac magnetic resonance (CMR)-derived strain to assess aortic valve (AV) annulus deformation during the cardiac cycle in regurgitant and well-functioning AVs. METHODS: Four patients with severe aortic regurgitation and seven healthy controls underwent CMR. Assessment of longitudinal strain was performed by hypothesizing the AV annulus would be the left ventricle in long-axis orientation. Longitudinal strain of the segments belonging to the muscular and fibrous AV annulus was weighted and averaged to obtain regional values (RLS). RESULTS: Comparison of RLS between regurgitant and well-functioning AVs showed a considerably different deformation of the muscular AV annulus (i.e., median RLS: 4.18 % [patients] vs. -10.41 % [controls], p = .024). The fibrous AV annulus demonstrated comparable deformational changes in both groups. CONCLUSION: CMR-derived strain allows for quantification of AV annulus deformation during the cardiac cycle and shows an altered RLS in the muscular AV annulus in patients with severe aortic regurgitation.
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Holst et al. (2022) conducted a case-control in Severe aortic regurgitation (n=11). Severe aortic regurgitation vs. Healthy controls with well-functioning aortic valves was evaluated on Regional longitudinal strain (RLS) of the muscular aortic valve annulus (p=0.024). Severe aortic regurgitation was associated with significantly altered deformation of the muscular aortic valve annulus during the cardiac cycle compared to healthy controls (median RLS 4.18% vs -10.41%, p=0.024).
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