Key result
Percutaneous PVL closure improves LVEF by ~15 points and reduces severe paravalvular regurgitation at 4 years.
Why the study?
Paravalvular leaks occur more frequently after TAVI because the transcatheter heart valve is anchored by radial force alone, and percutaneous closure is an increasingly performed alternative to surgery.
Case Report (n=1)
No
Answers are grounded in this paper and cite their sources.
Supports percutaneous PVL closure feasibility in select post-TAVI AR; leaves open confirmation in prospective trials.
Paravalvular leaks (PVLs) are not uncommon after surgical valve replacement.The need for re-operation for clinically significant leaks is between 1 and 3%. 1 Percutaneous PVL closure has become increasingly performed and is an alternative to surgery. 1 PVLs occur more frequently after transcatheter aortic valve implantation (TAVI), as the transcatheter heart valve (THV) is anchored by radial force alone. 24][5][6][7][8][9] We report a case of heart failure due to severe PVL after TAVI that has been treated with percutaneous repair with a good 4-year clinical outcome.A 72-year-old man presented with exertional dyspnoea (New York Heart Association [NYHA] Class III) over 6 months.Echocardiography demonstrated a severely impaired left ventricular ejection fraction (LVEF) of 30% and severe paravalvular AR around a bioprosthetic valve (Fig. 1A).Transoesophageal echocardiogram (TEE) confirmed severe paravalvular AR with a pressure half-time of 213ms, holodiastolic reversal in the descending thoracic aorta, and PVL jet occupying 35% of the prosthesis circumference.The PVL defect width was approximately 6mm.
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Chiam et al. (2021) conducted a case report in Severe paravalvular aortic regurgitation after transcatheter aortic valve implantation (TAVI) (n=1). Percutaneous paravalvular leak closure with an 8mm Amplatzer Vascular Plug 4 (AVP4) was evaluated on Paravalvular aortic regurgitation severity, LVEF, and NYHA functional class at 4 years. Percutaneous PVL closure using an 8mm AVP4 reduced paravalvular AR from severe to moderate, improving LVEF from 30% to 45% and sustaining NYHA Class II status at 4 years.
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