Key result
PVL closure with an 8-mm vascular plug and 24-mm balloon valvuloplasty resulted in complete PVL resolution and symptom relief in 1 patient with post-TAVR hemolysis.
Case Report (n=1)
A dual treatment approach using a vascular plug and balloon postdilatation can successfully treat complex paravalvular leak and hemolysis after TAVR.
May support dual therapy for select post-TAVR PVL; hypothesis-generating and should not yet change practice.
BACKGROUND: An 82-year-old man with prior transcatheter aortic valve replacement (TAVR) with an Edwards Sapien valve presented 30 months later with worsening anemia and mild dyspnea. Laboratory test results indicated hemolysis, and transthoracic echocardiography revealed moderate-to-severe aortic paravalvular leak (PVL) with a 2.3-mm perivalvular gap. CASE SUMMARY: The patient underwent PVL closure with an 8-mm vascular plug, followed by balloon valvuloplasty with a 24-mm True balloon, resulting in complete PVL resolution. The patient remained symptom free after the procedure, with no recurrence of anemia or heart failure. DISCUSSION: This case highlights the diagnosis and dual treatment approach for PVL-induced hemolysis after TAVR, using percutaneous closure with a vascular plug and balloon valvuloplasty. TAKE-HOME MESSAGE: When managing post-TAVR PVLs, incorporating both vascular plugs and balloon postdilatation may improve patient outcomes in select scenarios, such as complex PVLs, challenging anatomy, or failure of previous PVL repair.
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Mascara et al. (2025) conducted a case report in Paravalvular leak (PVL) after TAVR (n=1). PVL closure with a vascular plug and balloon valvuloplasty was evaluated on PVL resolution. PVL closure with an 8-mm vascular plug and 24-mm balloon valvuloplasty resulted in complete PVL resolution and symptom relief in 1 patient with post-TAVR hemolysis.
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