Key result
Celery leaf extract lowers blood pressure in hypertensive mice, plateauing at 300 mg/kg/day.
Why the study?
Celery (Apium graveolens) has been reported to possess antihypertensive properties, but evidence comparing the effects of different doses of aqueous celery leaf extract remained limited.
Does aqueous celery (Apium graveolens) leaf extract at doses of 300, 400, and 500 mg/kg/day reduce systolic and diastolic blood pressure in a NaCl-induced hypertensive murine model?
RCT (n=24)
Randomly assigned to four groups
Does aqueous celery (Apium graveolens) leaf extract at doses of 300, 400, and 500 mg/kg/day reduce systolic and diastolic blood pressure in a NaCl-induced hypertensive murine model?
Aqueous celery leaf extract significantly lowers systolic and diastolic blood pressure in NaCl-induced hypertensive mice, with no additional benefit observed at doses above 300 mg/kg/day.
Dose-dependent BP reduction by celery extract in rats; leaves open translation to human hypertension without clinical trials.
Background: Hypertension is a major risk factor for cardiovascular disease, and there is increasing interest in herbal medicines as complementary antihypertensive therapies. Celery (Apium graveolens) has been reported to possess antihypertensive properties; however, evidence comparing the effects of different doses of celery leaf extract remains limited. Objective: To evaluate the antihypertensive activity of aqueous celery (Apium graveolens) leaf extract at different dose levels in a NaCl-induced hypertensive murine model. Methods: Twenty-four male mice were rendered hypertensive by administration of 2% NaCl for seven days and were then randomly assigned to four groups (n = 6 per group): a control group and three treatment groups receiving aqueous celery leaf extract at doses of 300, 400, and 500 mg/kg body weight/day for seven consecutive days. Blood pressure was measured at baseline (Day 0), after hypertension induction (Day 7), and after treatment (Day 14). Post-treatment systolic and diastolic blood pressure values were compared among groups using one-way ANOVA followed by Tukey's honestly significant difference (HSD) test. Results: All treatment groups exhibited lower post-treatment systolic and diastolic blood pressure values than the control group. The 300 mg/kg body weight/day group showed the lowest post-treatment blood pressure values among the tested doses; however, no statistically significant differences were observed among the three treatment groups. Significant differences were identified between each treatment group and the control group (p < 0.05). Conclusion: Aqueous celery (Apium graveolens) leaf extract demonstrated antihypertensive activity in NaCl-induced hypertensive mice. Within the tested dose range, increasing the dose above 300 mg/kg body weight/day did not provide additional antihypertensive benefit. Further studies evaluating a wider range of doses, longer treatment durations, and maintenance of the hypertensive stimulus are warranted to better characterize the antihypertensive potential of celery leaf extract.
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Firdaus et al. (2026) conducted an RCT in NaCl-induced hypertension (n=24). Aqueous celery (Apium graveolens) leaf extract vs. Control group was evaluated on Post-treatment systolic and diastolic blood pressure values (p=<0.05). Aqueous celery leaf extract (300-500 mg/kg/day) significantly lowered systolic and diastolic blood pressure vs control in hypertensive mice (p<0.05), with no extra benefit above 300 mg/kg/day.
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