Key result
Novel prototype LAA occluder matches existing devices across bench and porcine models.
Why the study?
Because of limitations in anticoagulant therapy for preventing thromboembolic complications in atrial fibrillation, developing new domestically produced left atrial appendage occluders as an alternative is needed.
Does the new prototype left atrial appendage occluder model demonstrate advantages or non-inferiority compared to existing old-type models in silicone and porcine heart models?
Does the new prototype left atrial appendage occluder model demonstrate advantages or non-inferiority compared to existing old-type models in silicone and porcine heart models?
Answers are grounded in this paper and cite their sources.
Preclinical testing in silicone models and porcine hearts demonstrated that a new domestically produced prototype left atrial appendage occluder is non-inferior to existing models with no significant disadvantages identified.
Left atrial appendage occlusion is a non-pharmacological method for preventing thromboembolic complications in patients with atrial fibrillation. Due to the high prevalence of atrial fibrillation worldwide and in the Russian Federation, the number of patients requiring prevention of its thromboembolic complications with anticoagulant therapy is constantly increasing. However, because of certain limitations in its use, the development of new types of left atrial appendage occluders, particularly domestically produced ones, as an alternative to drug-based anticoagulation and their implementation in clinical practice is an extremely actual issue. Objective . To test a new left atrial appendage occluder model and demonstrate its advantages over the existing old-type model. Material and methods . Two experiments were conducted: 1) implantation of a prototype occluder into a silicone model of the left atrium; 2) implantation of a prototype occluder in the left atrial appendage of a porcine heart . Conclusions. A new model of left atrial appendage occluder was tested. Experiments on silicone models and fresh porcine hearts showed that the new model is not inferior to the existing ones, and no significant disadvantages of the new model were identified.
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Николаевич et al. (2026) studied Atrial fibrillation (thromboembolic complication prevention). New prototype left atrial appendage occluder vs. Existing old-type left atrial appendage occluder model was evaluated on Device implantation performance and comparison with existing occluder models. A new prototype left atrial appendage occluder tested in 2 experiments (silicone and porcine heart models) was not inferior to existing models, with no significant disadvantages identified.
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