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The ‘C5Me5Ru’ moiety coordinates at the A ring of estradiol to give both the α and β isomers of the ketonic form [Ru(C5Me5)(η5-estradienonyl)](1a and 1b respectively) and the α isomer of the phenolic form [Ru(C5Me5)(η6-estradiol)][PF6]2a; 1a reacts with HPF6 to give quantitatively 2a, but in the presence of NEt31a was regenerated.
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Vichard et al. (1991) studied this question.
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