Key result
Restrictive transmitral flow in acute MI is linked to ~4.6-fold higher in-hospital mortality.
Why the study?
This study evaluated the prognostic value of the admission Doppler transmitral flow pattern in patients with acute myocardial infarction.
Cohort (n=95)
May aid acute MI risk stratification; leaves open whether restrictive filling adds value beyond validated scores.
We analyzed the transmitral flow pattern on admission in 95 patients with acute myocardial infarction. Nineteen patients had a restrictive pattern, defined as a peak early to peak atrial filling wave ratio greater than 1.6, plus an early wave deceleration time shorter than 180 ms. Restrictive pattern, compared with nonrestrictive one, was associated with the development of heart failure (42 versus 11%, p = 0.001) and greater in-hospital mortality (32 versus 7%, p = 0.002). After multivariate analysis, it remained significantly predictive of death (p = 0.028). We conclude that a restrictive pattern of left ventricular filling in patients with acute myocardial infarction is an independent predictor of early outcome.
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García-Rubira et al. (2008) conducted a cohort in Acute myocardial infarction (n=95). Restrictive transmitral flow pattern (E/A ratio >1.6 and deceleration time <180 ms) vs. Nonrestrictive transmitral flow pattern was evaluated on In-hospital mortality (p=0.002). A restrictive transmitral flow pattern in acute MI was associated with higher in-hospital mortality (32% vs 7%, p=0.002) and heart failure (42% vs 11%, p=0.001).
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