HUBUNGAN ANTARA KADAR ASAM URAT DENGAN KADAR hs-CRP PADA PASIEN PROLANIS HIPERTENSI

Q: What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Hypertension (n=30). Intervention: Serum uric acid levels. Primary outcome: Correlation between serum uric acid levels and high-sensitivity C-reactive protein (hs-CRP) levels (r = -0.218, p=0.246).

Q: What does this research mean for the field?

Serum uric acid levels are not significantly associated with hs-CRP levels in female hypertensive PROLANIS patients. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Sofiyah Sofiyah; Anik Handayati; Suhariyadi Suhariyadi; Edy Haryanto

doi:10.51878/healthy.v5i4.15860

October 29, 2026HEALTHY Jurnal Inovasi Riset Ilmu KesehatanOpen Access

HUBUNGAN ANTARA KADAR ASAM URAT DENGAN KADAR hs-CRP PADA PASIEN PROLANIS HIPERTENSI

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Key result

Serum uric acid levels show no significant correlation with hs-CRP in female hypertensive patients.

r = -0.218
P=0.246
n=30

Why the study?

Elevated uric acid levels contribute to oxidative stress and inflammation, and this study sought to determine their relationship with the cardiovascular inflammatory biomarker hs-CRP in hypertensive Prolanis patients.

Is there a relationship between serum uric acid levels and hs-CRP levels in female patients aged 40-65 years with hypertension participating in the PROLANIS program?

Key Points

To determine the relationship between uric acid levels and high-sensitivity C-reactive protein (hs-CRP) levels among hypertensive Prolanis patients.
Conducted a quantitative observational analytic study with a cross-sectional design involving 30 female hypertensive Prolanis patients aged 40–65 years selected via purposive sampling.
Measured serum uric acid using a homogeneous enzymatic colorimetric method and hs-CRP using fluorescence immunoassay (FIA).
Assessed data normality with the Shapiro-Wilk test and evaluated the association between markers using Spearman rank correlation.
Patients presented with a mean uric acid level of 5.913 mg/dL and a mean hs-CRP level of 2.560 mg/L.
Spearman correlation demonstrated no statistically significant relationship between uric acid and hs-CRP levels (r = -0.218; p = 0.246), reflecting a very weak negative correlation.

Study Design

Type

Cross-Sectional (n=30)

Multicenter

No

Structured PICO

Is there a relationship between serum uric acid levels and hs-CRP levels in female patients aged 40-65 years with hypertension participating in the PROLANIS program?

P

Population

30 female patients aged 40-65 years with hypertension enrolled in the PROLANIS chronic disease management program in Bangkalan Regency, Indonesia, evaluated in a cross-sectional study.

E

Exposure

Measurement of serum uric acid levels using a homogeneous enzymatic colorimetric method (Automatic Biobase).

O

Outcome

Correlation between serum uric acid levels and serum high-sensitivity C-reactive protein (hs-CRP) levels measured by fluorescence immunoassay (FIA).surrogate

Main Result

Effect estimate: r = -0.218

p-value: p=0.246

Limitations

Small sample size (30 respondents) limiting the ability to detect weak relationships
Cross-sectional design cannot establish cause-and-effect relationships
Unmeasured confounding factors such as body mass index, kidney function, diabetes mellitus, diet, and medication use
Small sample size (30 respondents), which may limit the ability to detect weak relationships.
Cross-sectional design, which only describes conditions during the study period and cannot establish cause-and-effect relationships.
Unmeasured or uncontrolled confounding factors such as body mass index, kidney function, diabetes mellitus, diet, and medication use.

Implication

In female hypertensive patients aged 40-65 years participating in a chronic disease management program, serum uric acid levels were not significantly correlated with systemic inflammation as measured by hs-CRP, indicating these biomarkers should be evaluated independently.

Abstract

Hypertension is a chronic disease that may increase the risk of cardiovascular disease. Elevated uric acid levels are known to contribute to oxidative stress and inflammatory processes, while high-sensitivity C-reactive protein (hs-CRP) is an inflammatory biomarker used to assess cardiovascular disease risk. This study aimed to determine the relationship between uric acid and hs-CRP levels among hypertensive Prolanis patients at Farmalab Medical Laboratory, Bangkalan Regency. This study employed a quantitative observational analytic design with a cross-sectional approach. Serum samples were obtained from 30 hypertensive Prolanis patients. Uric acid levels were measured using an Homogenus Enzymatic Colometric method, while hs-CRP levels were measured using Fluorescence Immunoassay (FIA). Data were analyzed using the Shapiro-Wilk test and Spearman correlation. The mean uric acid level was 5.913 mg/dL and the mean hs-CRP level was 2.560 mg/L. Spearman correlation analysis showed no significant relationship between uric acid and hs-CRP levels (r = -0.218; p = 0.246). The correlation coefficient indicated a very weak negative relationship. In conclusion, uric acid levels were not significantly associated with hs-CRP levels among hypertensive Prolanis patients. ABSTRAK Hipertensi merupakan penyakit kronis yang berkaitan dengan peningkatan risiko penyakit kardiovaskular dan melibatkan proses inflamasi serta gangguan metabolik. Kadar asam urat yang meningkat diduga berkaitan dengan inflamasi sistemik, yang dapat dinilai melalui pemeriksaan high-sensitivity C-reactive protein (hs-CRP). Penelitian ini bertujuan untuk mengetahui hubungan antara kadar asam urat dan hs-CRP pada pasien Program Pengelolaan Penyakit Kronis (PROLANIS) hipertensi di Laboratorium Medis Farmalab, Kabupaten Bangkalan. Penelitian ini menggunakan desain kuantitatif analitik observasional dengan pendekatan cross-sectional. Sampel penelitian terdiri atas 30 pasien perempuan berusia 40–65 tahun yang dipilih menggunakan teknik purposive sampling. Pemeriksaan asam urat menggunakan metode homogeneous enzymatic colorimetric, sedangkan hs-CRP menggunakan metode fluorescence immunoassay (FIA). Analisis data dilakukan menggunakan uji normalitas Shapiro–Wilk dan korelasi Spearman. Hasil penelitian menunjukkan rata-rata kadar asam urat sebesar 5,913 mg/dL dan hs-CRP sebesar 2,560 mg/L. Uji korelasi Spearman menunjukkan koefisien korelasi sebesar −0,218 dengan nilai p = 0,246. Dengan demikian, tidak terdapat hubungan yang signifikan antara kadar asam urat dan hs-CRP pada pasien PROLANIS hipertensi.

Discussion

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Cite This Study

Sofiyah et al. (2026) conducted a cross-sectional in Hypertension (n=30). Serum uric acid levels was evaluated on Correlation between serum uric acid levels and high-sensitivity C-reactive protein (hs-CRP) levels (r = -0.218, p=0.246). Serum uric acid levels were not significantly correlated with hs-CRP levels (r = -0.218, p = 0.246) among female hypertensive PROLANIS patients.

synapsesocial.com/papers/6ae585624c46c197bbab4143 https://doi.org/10.51878/healthy.v5i4.15860

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HUBUNGAN ANTARA KADAR ASAM URAT DENGAN KADAR hs-CRP PADA PASIEN PROLANIS HIPERTENSI

Key Points

Study Design

Structured PICO

Main Result

Limitations

Implication

Abstract

Discussion

Cite This Study

HUBUNGAN ANTARA KADAR ASAM URAT DENGAN KADAR hs-CRP PADA PASIEN PROLANIS HIPERTENSI

Key Points

Study Design

Structured PICO

Main Result

Limitations

Implication

Abstract

Discussion

Cite This Study

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