Research progress of non-coding RNA-mediated regulation of the osteogenesis of periodontal tissues when mechanical tension is applied

Alveolar bone is the most active bone in the human skeleton. When stimulated by mechanical tension, periodontal osteoblast-related cells play a role in alveolar bone remodeling. During bone remodeling, non-coding RNAs (ncRNAs) actively participate in the regulation of osteogenesis, and mainly include microRNA (miRNA), long-chain non-coding RNA (lncRNA), and circular RNA(circRNA). This report aimed to review the current research of regulatory targets, pathways, and functions of cells and ncRNAs that play an important role in the osteogenesis in periodontal tissues when tension is applied.