Optimizing Quality of Life in Patients With Hypertension Through Comprehensive Pharmaceutical Care

Q: What are the key findings of this study?

Comprehensive pharmaceutical care significantly improved SF-36 quality of life, lowered systolic BP in 67.3% vs 1.0%, and improved disease knowledge in 98.1% vs 4.0% of patients (all P<0.05).

Q: What is the clinical evidence from this study?

Study design: RCT. Population: Hypertension (n=226). Intervention: Comprehensive pharmaceutical care (hypertension education, medication counseling, lifestyle and dietary leaflets) vs. Standard care without pharmaceutical care. Primary outcome: Health-related quality of life (SF-36 domain scores) (p=<0.05).

Q: What does this research mean for the field?

Pharmacist-led pharmaceutical care and patient counseling significantly improve health-related quality of life, disease knowledge, and blood pressure control in hypertensive patients. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.NEUTRAL.

Q: What question did this study set out to answer?

To evaluate the impact of pharmaceutical care on the quality of life of hypertensive patients, identify common anti-hypertensive drugs prescribed, and detect adverse drug reactions.

Shinu C; Faseeha Mariyam; Najwa Jifry; Fathima Mirfath T; Febi John; Fathima Hiba -; Asna Fathima; Sai Keerthana PC

doi:10.67440/ahj.vi.2934

October 4, 2026Adolescencia e SaudeOpen Access

Optimizing Quality of Life in Patients With Hypertension Through Comprehensive Pharmaceutical Care

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Key result

Comprehensive pharmaceutical care significantly improves quality of life and lowers systolic BP in hypertensive patients.

P<0.05
n=226

Why the study?

Hypertension is a major cardiovascular risk factor causing substantial mortality worldwide, prompting this evaluation of how pharmaceutical care affects quality of life, prescribed antihypertensive regimens, and adverse drug reactions in hospitalized hypertensive patients.

Does comprehensive pharmaceutical care and patient counselling improve health-related quality of life and blood pressure control in hospitalized patients with hypertension?

Key Points

To evaluate the impact of pharmaceutical care on the quality of life of hypertensive patients, identify common anti-hypertensive drugs prescribed, and detect adverse drug reactions.
A randomized, prospective, interventional study was conducted over a 1-year period among 226 hypertensive patients admitted to a general medicine department (113 randomly allocated to control and 113 to intervention).
Pharmaceutical care was administered to 104 patients in the intervention group through counseling regarding chronic condition management, lifestyle modifications, and medication safety, while 100 control group patients received no pharmaceutical care.
Health-related quality of life was evaluated before and after intervention using the SF-36 questionnaire across eight domains, alongside assessments of blood pressure and disease knowledge.
Quality of life domain scores on the SF-36 increased in the intervention group and decreased in the control group (P < 0.05).
Systolic and diastolic blood pressure decreased significantly in the intervention group compared to the control group (P < 0.05), with 70 patients (67.3%) showing systolic reduction and 67 patients (64.4%) showing diastolic reduction.
Knowledge improvement was classified as good in 104 patients (98.1%) in the intervention group versus 4 patients (4.0%) in the control group (P < 0.05), while adverse drug reactions occurred in 17.70% of intervention patients and 8.00% of controls.

Study Design

Type

RCT (n=226)

Blinding

Open-label

Randomization

Randomized

Multicenter

No

Structured PICO

Does comprehensive pharmaceutical care and patient counselling improve health-related quality of life and blood pressure control in hospitalized patients with hypertension?

P

Population

226 hospitalized adults (≥18 years, 35.85% female) with hypertension prescribed at least one antihypertensive drug at a tertiary care hospital in India, followed for 2 to 3 months within a 1-year study period.

I

Intervention

Comprehensive pharmaceutical care (n=113 randomized, 104 analyzed), including hypertension education, medication counselling, lifestyle modification changes, dietary regulations, a patient information leaflet in Malayalam, and a diet leaflet

C

Comparator

Standard care without any pharmaceutical care (n=113 randomized, 100 analyzed); both groups received prescribed antihypertensive medications

O

Outcome

Health-related quality of life (HRQoL) assessed before and after intervention (at 2-3 months follow-up) using the SF-36 health survey questionnairepatient reported

Main Result

p-value: p=<0.05

Pharmacist-led patient counselling and education significantly improved quality of life, disease knowledge, and blood pressure control among hospitalized patients with hypertension.

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Implication

Supports pharmaceutical care in hypertension; hypothesis-generating and requires larger trials before adoption.

Abstract

Hypertension is a major risk factor of cardiovascular disease and its complications account for many deaths yearly in the world. The aim of the study was to evaluate the impact of pharmaceutical care on quality of life of hypertensive patients. The objectives of the study include finding the common anti- hypertensive drugs prescribed and identifying any adverse drug reactions. A randomized, prospective, interventional study was done on 226 hypertensive patients who were admitted to the General Medicine department for a period of 1year. Pharmaceutical care was given to 104 patients from intervention group and the 100 patients from control group were not given any pharmaceutical care. The quality of life of the control and intervention group patients were compared before and after intervention using SF-36 questionnaire. The result shows that the quality of life increase in the Intervention group (P value <0.05) compared to the Control group. The Systolic and Diastolic blood pressure decreased in the Intervention group (P < 0.05) compared to the Control group. The patient knowledge also showed significant increase in the Intervention group patients (P <0.05) compared to Control group. The study showed that providing pharmaceutical care to hypertensive patients increased their quality of life and also the knowledge of the disease and medications. This study concludes that providing pharmaceutical care to Hypertensive patients in the form of patient counselling can improve the quality of life of these patients.

Discussion

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Cite This Study

C et al. (2026) conducted an RCT in Hypertension (n=226). Comprehensive pharmaceutical care (hypertension education, medication counseling, lifestyle and dietary leaflets) vs. Standard care without pharmaceutical care was evaluated on Health-related quality of life (SF-36 domain scores) (p=<0.05). Comprehensive pharmaceutical care significantly improved SF-36 quality of life, lowered systolic BP in 67.3% vs 1.0%, and improved disease knowledge in 98.1% vs 4.0% of patients (all P<0.05).

synapsesocial.com/papers/6ae7d421edffb496294104ca https://doi.org/10.67440/ahj.vi.2934

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Optimizing Quality of Life in Patients With Hypertension Through Comprehensive Pharmaceutical Care

Key Points

Study Design

Structured PICO

Main Result

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Optimizing Quality of Life in Patients With Hypertension Through Comprehensive Pharmaceutical Care

Key Points

Study Design

Structured PICO

Main Result

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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