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Kidney tubular secretion eliminates many endogenous and exogenous substances that are not eliminated or are only partially eliminated by glomerular filtration.1 Endogenous secreted solutes have facilitated the assessment of tubular secretion using simple paired blood and urine samples.1 Prior studies have demonstrated that reduced tubule secretion is associated with risk of chronic kidney disease (CKD) progression.2
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Bullen et al. (2025) studied this question.
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