Key result
Hyponatremia in acute STEMI is linked to a ~3-fold higher rate of cardiogenic shock.
Why the study?
Acute ST-elevation myocardial infarction is frequently complicated by hyponatremia, and its prognostic significance for in-hospital outcomes required further evaluation.
Does admission hyponatremia (serum sodium <135 mEq/L) predict worse in-hospital clinical outcomes (arrhythmias, cardiogenic shock, heart failure, ICU admission, and mortality) compared to normonatremia in adult patients presenting with acute ST-elevation myocardial infarction?
Cross-Sectional (n=100)
No
Does admission hyponatremia (serum sodium <135 mEq/L) predict worse in-hospital clinical outcomes (arrhythmias, cardiogenic shock, heart failure, ICU admission, and mortality) compared to normonatremia in adult patients presenting with acute ST-elevation myocardial infarction?
Answers are grounded in this paper and cite their sources.
Admission hyponatremia is a frequent finding in acute STEMI patients and serves as a simple, inexpensive prognostic marker strongly associated with increased risk of in-hospital heart failure, cardiogenic shock, arrhythmias, and ICU admission.
Acute ST-elevation myocardial infarction is frequently complicated by hyponatremia, but its prognostic significance for in-hospital outcomes requires further evaluation. Therefore, it is of interest to assess the incidence and prognostic value of hyponatremia in 100 patients with acute ST-elevation myocardial infarction by comparing clinical outcomes between hyponatremic and normonatremic groups. Hyponatremia was present in 57% of patients, with 29% having moderate hyponatremia and was significantly associated with arrhythmias (73.7% vs. 51.2%; p = 0.024), cardiogenic shock (94.7% vs. 30.2%; p < 0.001), intensive care unit admission (70.2% vs. 23.3%; p < 0.001) and heart failure (63.2% vs. 27.9%; p < 0.001). Increasing severity of hyponatremia was associated with progressively worse in-hospital outcomes, although the higher mortality observed did not reach statistical significance. Thus, serum sodium is a simple, inexpensive prognostic marker that can improve early risk stratification and clinical management in acute ST-elevation myocardial infarction.
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Devendra Ahirwar (2026) conducted a cross-sectional in Acute ST-elevation myocardial infarction (STEMI) (n=100). Hyponatremia (serum sodium <135 mEq/L) vs. Normonatremia (serum sodium >=135 mEq/L) was evaluated on In-hospital cardiogenic shock (p=<0.001). Hyponatremia was present in 57% of acute STEMI patients and significantly increased cardiogenic shock (94.7% vs. 30.2%, p<0.001) and heart failure (63.2% vs. 27.9%, p<0.001).
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