Key result
Pindolol reduces peripheral vascular resistance at maximal vasodilatation in essential hypertension, suggesting reversible changes.
Why the study?
Although various beta-adrenoceptor antagonists are equally effective in lowering blood pressure in patients with essential hypertension, their mechanisms of action are heterogeneous, with pindolol appearing to act via peripheral vascular mechanisms.
Answers are grounded in this paper and cite their sources.
Pindolol's ISA may differentiate vascular responses in hypertension; leaves open whether this alters clinical outcomes versus other beta-blockers.
In recent years evidence has accumulated which indicates that although various beta-adrenoceptor antagonists are equally effective in lowering blood pressure in patients with essential hypertension the mechanisms of action of the different drugs are heterogeneous. 2. Pindolol, a beta-adrenoceptor antagonist with pronounced intrinsic sympathomimetic activity (ISA) appears, to some extent, to act via peripheral vascular mechanisms. 3. Following prolonged treatment with pindolol in essential hypertension peripheral vascular resistance at maximal vasodilatation has been found to be decreased compared with the pretreatment values suggesting that the structural vascular changes characteristic of established hypertension may be reversible.
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HANS DUNÉR (1987) conducted a review in Essential hypertension. Pindolol vs. Pretreatment values / other beta-adrenoceptor antagonists was evaluated on Peripheral vascular resistance at maximal vasodilatation. Prolonged pindolol treatment in essential hypertension decreased peripheral vascular resistance at maximal vasodilatation compared with pretreatment values, suggesting reversible vascular changes.
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