Key result
Hypertension accelerates aortic remodelling, senescence, and calcification by ~24 weeks in rat models.
Why the study?
The effects of hypertension on vascular remodelling, ageing, and calcification were not fully understood.
Does spontaneous hypertension accelerate and augment ageing-related aorta remodelling, senescence, and calcification in rats?
Does spontaneous hypertension accelerate and augment ageing-related aorta remodelling, senescence, and calcification in rats?
Answers are grounded in this paper and cite their sources.
In a preclinical rat model, spontaneous hypertension significantly accelerates the onset and progression of ageing-related aortic remodelling, cellular senescence, and vascular calcification.
The effects of hypertension on vascular remodelling, ageing and calcification are not fully understood. In this study, we monitored the dynamic changes of aorta remodelling, senescence and calcification in spontaneously hypertensive rats (SHRs) during ageing. RESULTS: Vascular remodelling and senescence cells occurred in SHR aortas at 24 weeks. The calcium content and calcium deposition of the aorta increased in SHRs at 48 weeks. All of these changes became increasingly significant with ageing. In contrast, these pathologic changes appeared in Wistar-Kyoto (WKY) normotensive rats at a much later stage (72 weeks). These data showed that the ageing-related aorta remodelling, senescence and calcification in SHRs occurred earlier and progressed more severely than in WKY rats. CONCLUSION: Ageing-related vascular remodelling and calcification were accelerated and augmented in SHR aortas.
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Shi et al. (2018) studied Spontaneous hypertension. Spontaneous hypertension during ageing vs. Wistar-Kyoto (WKY) normotensive rats was evaluated on Dynamic changes of aorta remodelling, senescence and calcification. Spontaneously hypertensive rats developed aortic remodelling and senescence at 24 weeks and increased aortic calcification at 48 weeks, compared with 72 weeks in normotensive WKY rats.
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