Peptide Bioconjugates: an Emerging Strategy in the Pharmacotherapy of Dermatological Diseases (2015-2025). A Review

Peptide-based bioconjugates are emerging as a highly versatile and powerful class of therapeutics in modern dermatology, offering precise molecular targeting combined with the flexibility of advanced chemical design. These systems demonstrate broad applicability — from antimicrobial and anti-inflammatory interventions to photodynamic and antineoplastic therapies — while addressing key limitations of conventional treatments through controlled delivery, sustained release, and enhanced cellular selectivity. Ongoing advancements in peptide engineering, linker chemistry, and conjugation strategies will be critical for successful clinical translation. The systematic review examines the most recent advances in peptide-based therapeutics across major dermatological conditions, highlighting translational progress achieved between 2015 and 2025.