Key result
Coenzyme Q10 increases LVEF by ~5 points in pediatric dilated cardiomyopathy.
Why the study?
Heart failure imposes a heavy burden on the health care system, and the effect of coenzyme Q10 supplementation on echocardiographic parameters in children with heart failure due to dilated cardiomyopathy warranted investigation.
Does oral coenzyme Q10 supplementation improve echocardiographic parameters (ejection fraction and fractional shortening) in children with heart failure due to dilated cardiomyopathy?
Does oral coenzyme Q10 supplementation improve echocardiographic parameters (ejection fraction and fractional shortening) in children with heart failure due to dilated cardiomyopathy?
In this small single-arm pilot trial, 2 months of oral coenzyme Q10 supplementation was associated with modest improvements in left ventricular ejection fraction and fractional shortening in children with dilated cardiomyopathy, warranting controlled trials.
Answers are grounded in this paper and cite their sources.
Does not support routine coenzyme Q10 use in pediatric HF; leaves open efficacy pending randomized trials.
Background: Heart failure (HF) is one of the most common and complex heart diseases that has a heavy burden on the health care system. Considering the role of supplements in improving heart diseases and increasing the quality of life of patients, in this study we aimed to investigate the effect of coenzyme Q10 on echocardiographic parameters in children with heart failure due to dilated cardiomyopathy. Methods: In this pilot single-arm clinical trial, fifteen children with heart failure were included after obtaining written consent and medical history. They first underwent echocardiography and then were treated with oral coenzyme Q10, 10 mg/kg daily for 2 months. Then they underwent echocardiography again and the information was collected. Data were entered into SPSS ver. 20 software and depending on the data distribution, appropriate paired statistical tests were applied. Conclusion: In this study, echocardiographic parameters of patients with HF due to dilated cardiomyopathy significantly improved after receiving coenzyme Q10, which indicates the possible positive effect of coenzyme Q10 on heart function and can probably be used in the treatment program of patients. Due to the pilot design of this study, more studies are needed in this field.
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Rajaei et al. (2026) studied Heart failure due to dilated cardiomyopathy (n=15). Coenzyme Q10 vs. Baseline (pre-treatment paired comparison; single-arm trial) was evaluated on Left ventricular ejection fraction (EF) before vs after 2 months of Coenzyme Q10 (p=<0.001). Oral coenzyme Q10 increased mean ejection fraction from 38.87% to 43.40% and fractional shortening from 23.73% to 25.73% in children with dilated cardiomyopathy.
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