Zhenwu Decoction Combined with Other Traditional Chinese Medicine Methods for the Treatment of Chronic Heart Failure of Yang Deficiency and Blood Stasis Type

Q: What is the clinical evidence from this study?

Study design: Review. Population: Chronic Heart Failure of Yang Deficiency and Blood Stasis Type. Intervention: Zhenwu Decoction combined with other Traditional Chinese Medicine methods (such as Xuefu Zhuyu Decoction, Danshen Yin, Guizhi Fuling Pills, moxibustion, acupuncture, acupoint application, and Baduanjin) vs. Conventional Western medical therapy.

丹钖 王

doi:10.12677/acm.2026.16103468

January 1, 2026Advances in Clinical MedicineOpen Access

Zhenwu Decoction Combined with Other Traditional Chinese Medicine Methods for the Treatment of Chronic Heart Failure of Yang Deficiency and Blood Stasis Type

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Key result

Zhenwu Decoction combinations improve cardiac function and inhibit ventricular remodeling in chronic heart failure.

Why the study?

Conventional Western medical therapy for chronic heart failure is associated with multiple adverse effects and contraindications, prompting increasing clinical emphasis on traditional Chinese medicine approaches centered on Zhenwu Decoction.

Key Points

To review therapeutic strategies for chronic heart failure presenting with yang deficiency and blood stasis, focusing on Zhenwu Decoction combined with other herbal formulas and external Chinese medicine modalities.
Reviewed literature evaluating combinations of Zhenwu Decoction with formulas such as Xuefu Zhuyu Decoction, Danshen Drink, and Guizhi Fuling Pill.
Summarized mechanistic and clinical evidence for external adjuncts, including moxibustion (and umbilical moxibustion), acupuncture, acupoint plaster application, and Baduanjin qigong exercise.
Combining Zhenwu Decoction with formulas such as Xuefu Zhuyu Decoction or Guizhi Fuling Pill reduces inflammatory cytokines including TNF-α and IL-6, improves left ventricular ejection fraction, and inhibits ventricular remodeling.
Adjunctive external therapies like moxibustion and acupoint application demonstrate potential to downregulate Caspase 3 and MyD88 expression, lower BNP levels, and improve exercise tolerance.
The authors emphasize that existing literature remains limited by small sample sizes, lack of Zhenwu Decoction monotherapy control groups, and an absence of large-scale multicenter randomized controlled trials.

PICO

P

Population

Chronic Heart Failure of Yang Deficiency and Blood Stasis Type

I

Intervention / Comparator

Zhenwu Decoction combined with other Traditional Chinese Medicine methods (such as Xuefu Zhuyu Decoction, Danshen Yin, Guizhi Fuling Pills, moxibustion, acupuncture, acupoint application, and Baduanjin) vs Conventional Western medical therapy

Limitations

Existing studies primarily focus on heart-kidney Yang deficiency with blood stasis and water retention syndromes, with limited research on other syndrome types.
Literature quality is relatively low and sample sizes are small.
Combined therapy trials often lack a control group using Zhenwu Decoction alone and lack long-term follow-up observations.
Research on Zhenwu Decoction focuses mostly on clinical efficacy rather than network pharmacology and molecular mechanisms, lacking multicenter, large-sample randomized controlled trial evidence.

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Implication

May support TCM adjuncts in chronic HF; hypothesis-generating and should not change practice without RCTs.

Abstract

Heart failure is a prevalent cardiovascular disease that profoundly compromises patients' quality

Discussion

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Cite This Study

丹钖王 (2026) conducted a review in Chronic Heart Failure of Yang Deficiency and Blood Stasis Type. Zhenwu Decoction combined with other Traditional Chinese Medicine methods (such as Xuefu Zhuyu Decoction, Danshen Yin, Guizhi Fuling Pills, moxibustion, acupuncture, acupoint application, and Baduanjin) vs. Conventional Western medical therapy was evaluated. Zhenwu Decoction combined with blood-activating formulas or external TCM therapies improves cardiac function, reduces inflammatory markers (TNF-alpha, IL-6), and inhibits ventricular remodeling in chronic heart failure.

synapsesocial.com/papers/6af0db863c845ca7837ced4f https://doi.org/10.12677/acm.2026.16103468

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Zhenwu Decoction Combined with Other Traditional Chinese Medicine Methods for the Treatment of Chronic Heart Failure of Yang Deficiency and Blood Stasis Type

Key Points

PICO

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Zhenwu Decoction Combined with Other Traditional Chinese Medicine Methods for the Treatment of Chronic Heart Failure of Yang Deficiency and Blood Stasis Type

Key Points

PICO

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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