Key result
Elevated atherogenic index of plasma is linked to ~2.5-fold higher odds of subclinical CAD.
Why the study?
The atherogenic index of plasma, triglyceride-glucose index, and monocyte-to-lymphocyte ratio are strongly associated with coronary atherogenesis, motivating an investigation of their association with and ability to predict subclinical CAD.
Cross-Sectional (n=697)
No
Answers are grounded in this paper and cite their sources.
These indices may aid subclinical CAD risk stratification; hypothesis-generating and should not yet change practice.
Background: The atherogenic index of plasma (AIP), triglyceride-glucose (TyG) index, and monocyte-to-lymphocyte ratio (MLR) are strongly associated with atherogenesis of the coronary artery. This study aimed to investigate the association of the AIP, TyG index, and MLR with subclinical coronary artery disease (CAD) and evaluate their ability to predict subclinical CAD.Methods: A total of 697 asymptomatic patients were enrolled in this study and assigned to the subclinical CAD group (n=332) and control group (n=365). The clinical data, coronary artery calcification score, and calculated AIP, TyG index, and MLR were collected by graduate students in the cardiology division. Multivariate logistic regression models were set up to assess the risk factors for subclinical CAD.Results: The AIP, TyG index and MLR values were higher in the subclinical CAD group than in the control group (all P<0.05). In addition to the classic independent clinical risk factors, increased AIP, TyG index and MLR values were all independent risk factors for subclinical CAD (all P<0.05). The AUCs were higher after combining clinical risk factors than the AIP, TyG index, or MLR alone (all P<0.05).Conclusions: The AIP, TyG index and MLR are independent risk factors for subclinical CAD, which can be useful for improving the diagnosis and prevention of CAD.
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Si et al. (2021) conducted a cross-sectional in Subclinical coronary artery disease (n=697). Elevated Atherogenic Index of Plasma (AIP ≥ -0.253), Triglyceride-Glucose (TyG) index (≥ 8.04), and Monocyte-to-Lymphocyte Ratio (MLR ≥ 0.142) vs. Lower biomarker levels / Control group (CACS = 0) was evaluated on Subclinical coronary artery disease (defined as CACS ≥ 100 Agatston Units and/or ≥ 50% coronary luminal stenosis) (OR 2.530, 95% CI 1.252, 5.114, p=0.010). Elevated atherogenic index of plasma (OR 2.530), TyG index (OR 2.007), and monocyte-to-lymphocyte ratio (OR 1.693) were independent risk factors for subclinical coronary artery disease.
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