Regenerative effects of human placenta hydrolysate in an experimental model of accelerated aging

Standardized human placental hydrolysates (SHPs) contain peptides exhibiting regenerative, hepatoprotective, and geroprotective properties. The effects of SHP “Laennec” (Japan Bioproducts, Japan) were studied in a rat model of accelerated aging (n=30) induced by D-galactose in combination with palm oil, L-methionine in the diet, sodium chloride in drinking water, and ferrous sulfate. This model resulted in a complex of neurological, somatic, biochemical, and histological abnormalities indicating accelerated development of multiple organ pathology. This accelerated aging model negatively impacts hematopoiesis (impaired red blood cell and platelet size distribution, abnormal levels of other blood cells) and increases chronic systemic inflammation (ESR, leukocyte levels, including neutrophils, lymphocytes, monocytes, etc.). For most parameters, the use of Laennec resulted in the return of the corresponding values to the normal ranges characteristic of intact animals. Histological analysis showed that Laennec HPG helped eliminate fatty degeneration and iron overload in the liver, kidneys, brain, myocardium, and skin, also reducing lipofuscin deposits in the tissues. Laennec HPG peptides that may promote geroprotection (JBP485, HVLEFAL, SENALVA, YGGFM, ELLQTG, etc.) were identified. An improvement in the clinical condition of animals was observed with a course of treatment with Laennec HPG in an accelerated aging model.