Key result
Conservative therapy resolves McConnell's sign and nearly triples TAPSE/sPAP in isolated RV infarction.
Why the study?
McConnell's sign was initially considered highly specific for acute pulmonary embolism, but evidence indicates it may also appear in other conditions involving RV dysfunction.
Case Report (n=1)
No
This case demonstrates that McConnell's sign is not pathognomonic for acute pulmonary embolism and can occur in right ventricular myocardial infarction, while highlighting the utility of the TAPSE/sPAP ratio for monitoring right ventricular recovery.
Answers are grounded in this paper and cite their sources.
McConnell's sign warrants diagnostic caution beyond PE; leaves open prospective validation of its specificity and TAPSE/sPAP for RV recovery monitoring.
McConnell′s sign, defined as hypokinesis of the right ventricular (RV) midfree wall with preserved apical contractions, was initially considered to be highly specific for acute pulmonary embolism. However, evidence indicates that it may also appear in other conditions involving RV dysfunction. Here, we report a case of McConnell′s sign associated with RV myocardial infarction in the absence of pulmonary embolism. A 74‐year‐old female was successfully resuscitated following cardiac arrest. Echocardiography revealed a dilated RV with moderate tricuspid regurgitation and a regional wall motion pattern characteristic of McConnell′s sign. Contrast‐enhanced computed tomography excluded a pulmonary embolism. Coronary angiography revealed an occluded right coronary artery, which was identified as the culprit lesion, and a chronically occluded left anterior descending artery with collateral flow. Conservative management led to gradual clinical and echocardiographic improvement. This case underscores that McConnell′s sign is not pathognomonic for pulmonary embolism and should be interpreted cautiously.
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Munekata et al. (2026) conducted a case report in Right ventricular myocardial infarction presenting with McConnell's sign in the absence of pulmonary embolism (n=1). Conservative medical management following discontinued percutaneous coronary intervention was evaluated on Right ventricular–pulmonary artery coupling (TAPSE/sPAP ratio) and resolution of McConnell's sign. Conservative management in a 74-year-old with RV infarction without PE resolved McConnell's sign and improved the TAPSE/sPAP ratio from 0.21 to 0.58 mm/mmHg at 1 month.
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