Why the study?
Primary cardiac leiomyosarcoma is an extremely rare malignancy that is often misdiagnosed as benign atrial myxoma.
Case Report (n=1)
No
Aggressive repeated surgical resections combined with local cryoablation may offer viable disease control in patients with recurrent primary cardiac leiomyosarcoma refractory to adjuvant chemotherapy.
Answers are grounded in this paper and cite their sources.
May support aggressive resection plus cryoablation in refractory cardiac leiomyosarcoma; leaves open prospective validation in larger cohorts.
Primary cardiac leiomyosarcoma is an extremely rare malignancy often misdiagnosed as benign atrial myxoma. A 55-year-old male presented with syncope from a recurrent left atrial mass, eight months after initial resection for a presumed myxoma at another center. Redo median sternotomy and macroscopic tumor resection confirmed leiomyosarcoma with R1 margins. Despite adjuvant ifosfamide, mesna, doxorubicin chemotherapy, early cardiac magnetic resonance imaging demonstrated local recurrence. A third surgical resection was performed, combined with left atrial cryoablation and mitral annuloplasty. At 6-month follow-up, the patient remains alive without recurrence or metastasis. Aggressive repeated resections with local cryoablation may provide viable disease control in recurrent cardiac leiomyosarcoma.
No takes yet. Share an insight, caveat, or question.
Koç et al. (2026) conducted a case report in Recurrent left atrial leiomyosarcoma (n=1). Repeated surgical resection combined with left atrial cryoablation and mitral annuloplasty (following prior redo sternotomy and adjuvant ifosfamide, mesna, and doxorubicin) was evaluated on Survival without recurrence or metastasis at 6-month follow-up.
Synapse has enriched 10 related papers. Consider them for comparative context: