Key result
Higher systolic BP is linked to ~4% higher odds of elevated CAVI0.
Why the study?
Although the cardio-ankle vascular index (CAVI) and its mathematically corrected formula (CAVI0) are theoretically independent of blood pressure, assessing their association with blood pressure indices on the right and left sides can reveal the importance of considering patient blood pressure with respect to age.
Cross-Sectional (n=163)
No
Answers are grounded in this paper and cite their sources.
Supports CAVI0 as a diastolic BP-independent arterial stiffness metric; leaves open whether this mathematical correction improves longitudinal cardiovascular risk stratification over standard CAVI.
Background and Objectives: The cardio-ankle vascular index (CAVI) is an index for arterial stiffness that is theoretically independent of blood pressure. CAVI0 is the mathematically corrected formula of CAVI that has been claimed to be less dependent on blood pressure changes. The association of right and left CAVI and CAVI0 with blood pressure indices can reveal the importance of considering the blood pressure of the patient despite their theoretical independency. In this study, we assessed the right and left CAVI and CAVI0 and evaluated the main effect of blood pressure indices on them with respect to age. Materials and Methods: We collected the following data of 136 community-dwelling individuals: age; sex; weight; height; body mass index; right and left CAVI and CAVI0; and systolic (SBP), diastolic (DBP), and mean blood pressure (MBP). The association of right and left CAVI and CAVI0 with blood pressure indices was evaluated using regression analysis. Results: Regression analysis revealed that SBP, DBP, and MBP were associated with right and left CAVI (independent of age). Moreover, SBP was associated with both right and left CAVI0 (independent of age), whereas DBP was not associated with right or left CAVI0. Conclusion: Right and left arterial stiffness measured using CAVI has no different associations with SBP, DBP, and MBP. Both right and left CAVI0 were independently associated with SBP, whereas neither left nor right CAVI0 was independently associated with DBP. MBP was only associated with the right-side CAVI0 in community-dwelling individuals.
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Hung et al. (2022) conducted a cross-sectional in Atherosclerosis / Arterial stiffness (n=163). Systolic blood pressure (SBP) was evaluated on High right-side mathematically corrected cardio-ankle vascular index (CAVI0 ≥ 75th percentile, age-adjusted) (OR 1.039, 95% CI 1.013-1.065, p=0.003). Systolic blood pressure was independently associated with high right CAVI0 and left CAVI0, unlike diastolic blood pressure.
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