Key result
Exercise reverses multisystem sedentarism-related changes and serves as an effective therapy for HFpEF.
This review explores the shared pathophysiological effects of sedentarism and HFpEF on organ systems and evaluates exercise rehabilitation as a preventative and therapeutic strategy.
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Supports exercise regimens in HFpEF; leaves open mortality benefits pending prospective trials.
Sedentarism has a ubiquitous presence in contemporary society and is a growing issue across Asia. Heart failure with preserved ejection fraction (HFpEF) has an increasing prevalence, and its pathophysiology and cardiac structural changes are closely linked to cardiac changes seen with sedentarism. Both sedentarism and HFpEF lead to increased mortality. Their systemic effects, underpinned by metabolic dysfunction driving chronic sterile inflammation, are felt in most organ systems. This review highlights the effects of sedentarism and HFpEF on organ systems and how exercise can remediate these changes. It will focus on the cardiovascular, skeletal, and respiratory systems, providing insight into molecular mechanisms. It will then review the benefits of exercise on each organ system and explore the utility of exercise as a treatment option for HFpEF, focusing on evidence from exercise trials in HFpEF. Finally, the review will propose an exercise rehabilitation regimen for the prevention and treatment of HFpEF.
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Kamaladasa et al. (2026) conducted a review in Heart failure with preserved ejection fraction (HFpEF). Exercise vs. Sedentarism was evaluated. Exercise remediates the systemic cardiovascular, skeletal, and respiratory changes linked to sedentarism and serves as a treatment option for HFpEF.
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