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January 14, 2026PLoS PathogensOpen Access

Basal IFNλ2/3 signaling is required for ISG expression and viral control in human intestinal epithelial cells

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Authors

YKYağmur KeserZBZehra Sena BuminAVAmelia Perez Valiente

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Overview

Investigating IFNλ2/3's role in antiviral immunity in intestinal epithelial cells suggests its critical involvement in immune readiness.

Key Points

  • This study aims to define the specific roles of IFNλ2/3 in antiviral immunity in intestinal epithelial cells.
  • Utilized human intestinal epithelial T84 cells for experimentation.
  • Conducted genetic depletion of IFNλ1 or IFNλ2/3 to assess their individual contributions.
  • Performed transcriptomic profiling to analyze ISG expression levels.
  • Basal IFNλ2/3 is vital for controlling the replication of various viruses such as VSV and MRV.
  • IFNλ2/3 depletion led to reduced STAT1 protein levels and impaired response to exogenous IFNλ.
  • IFNλ2/3 was necessary for activating paracrine JAK/STAT signaling in surrounding cells.

Cite This Study

Keser et al. (2026) studied this question.

synapsesocial.com/papers/6967191987ba607552bb90echttps://doi.org/10.1371/journal.ppat.1013857
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Basal IFN-λ2/3 expression mediates tight junction formation in human epithelial cells2025
  2. 2Subtype-specific functions of basal IFNλs2026
  3. 3IFN-λ determines the intestinal epithelial antiviral host defense2011 · 419 citations
  4. 4A paradox of transcriptional and functional innate interferon responses of human intestinal enteroids to enteric virus infection2017 · 130 citations
  5. 5Expression of <i>Ifnlr1</i> on Intestinal Epithelial Cells Is Critical to the Antiviral Effects of Interferon Lambda against Norovirus and Reovirus2017 · 167 citations