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January 1, 2002Respiration

In vivo Platelet Activation Is Increased during Sleep in Patients with Obstructive Sleep Apnea Syndrome

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Why the study?

Is in vivo platelet activation increased during sleep in patients with OSAS, and does CPAP therapy affect it?

Population

12 patients with untreated obstructive sleep apnea syndrome and 6 healthy volunteer controls

Comparison

Continuous positive airway pressure therapy for… vs Healthy volunteers and baseline untreated state

Design

Case-control

Follow-up

1 night

Authors

TGThomas GeiserFBFlorian M. BuckBMBeat J. Meyer

Discussion

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Overview

May link nocturnal platelet activation to OSAS cardiovascular risk; hypothesis-generating for CPAP effects.

Structured PICO

Is in vivo platelet activation increased during sleep in patients with OSAS, and does CPAP therapy affect it?

P
Population
12 patients with untreated obstructive sleep apnea syndrome (OSAS) and 6 healthy volunteer controls (total n=18)
I
Intervention
Continuous positive airway pressure (CPAP) therapy for 1 night
C
Comparator
Healthy volunteers and baseline untreated state
O
Outcome
In vivo platelet activation (percentage of platelets positive for CD63 and CD62P) and generation of procoagulant platelet-derived microparticles (PMP) during and after sleep (4 and 7 a.m.)surrogate

Patients with OSAS exhibit increased in vivo platelet activation during sleep, providing a potential mechanism for their elevated risk of cardiovascular events.

Cite This Study

Geiser et al. (2002) studied this question.

synapsesocial.com/papers/6a100d21b6f5ee0401603abahttps://doi.org/10.1159/000063625
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Association between mean platelet volume and severity of disease in patients with obstructive sleep apnea syndrome without risk factors for cardiovascular disease2013 · 29 citations
  2. 2Mean Platelet Volume in Patients With Obstructive Sleep Apnea Syndrome and Concurrent Hypertension and Diabetes Mellitus2020 · 2 citations
  3. 3Comparison of Platelet Indices in Patients with Obstructive Sleep Apnea and Obstructive Lung Diseases + Obstructive Sleep Apnea Syndrome2025
  4. 4Alterations in platelets according to the severity of obstructive syndrome of apnoea-hypopnea2013
  5. 5The Associations of Platelet Activation and Coagulation Parameters with Obstructive Sleep Apnoea: A Large-Scale Observational Study2023 · 6 citations