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March 1, 1991AJP Cell Physiology

Oleic acid rapidly and reversibly decreased gap junction permeability and conductance, uncoupling cells at membrane concentrations as low as 1 mol%, whereas decanoic acid required upwards of 35 mol%.

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Population

Pairs of neonatal rat heart cells

Design

Preclinical

Authors

JBJanis M. BurtKMKenneth MasseyBMB. N. Minnich

Discussion

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Overview

May link oleic acid to ischemic arrhythmias; hypothesis-generating for human gap junction studies.

Structured PICO

P
Population
Pairs of neonatal rat heart cells
I
Intervention
Oleic acid, other unsaturated fatty acids (C-18: cis 6, 9, or 11, and C-18, 16, and 14, cis 9), saturated fatty acids (C-10, 12, and 14), and saturated fatty alcohols (C-8, 10, and 12)
O
Outcome
Permeability and conductance of gap junctions (cellular uncoupling)surrogate

Free fatty acids such as oleic acid rapidly uncouple cardiac gap junctions, providing a potential mechanism for the initiation of arrhythmias during and after ischemic insults.

Cite This Study

Burt et al. (1991) studied this question.

synapsesocial.com/papers/6a16411da2d9d2b88ec50d60https://doi.org/10.1152/ajpcell.1991.260.3.c439
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Oleic acid differentially affects gap junction-mediated communication in heart and vascular smooth muscle cells1993 · 45 citations
  2. 2Cardiac Ischemia and Uncoupling: Gap Junctions in Ischemia and Infarction2006 · 50 citations
  3. 3Suppression of voltage-gated L-type Ca <sup>2+</sup> currents by polyunsaturated fatty acids in adult and neonatal rat ventricular myocytes1997 · 385 citations
  4. 4Uncoupling of cardiac cells by doxyl stearic acids specificity and mechanism of action1989 · 48 citations
  5. 5Mechanism of heptanol-induced uncoupling of cardiac gap junctions: a perforated patch-clamp study1992 · 154 citations