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January 1, 2005EP Europace

New developments in a strongly coupled cardiac electromechanical model

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Population

Coupled three-dimensional computational model of cardiac electromechanics

Comparison

Inclusion of cellular electrical heterogeneity vs Electrically homogeneous cell model

Design

Preclinical

Authors

DNDavid NickersonNSNicolas P. SmithPHPeter Hunter

Discussion

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Overview

Supports heterogeneous APD in ventricular models; hypothesis-generating for electromechanical research, untested in humans.

Structured PICO

P
Population
Coupled three-dimensional computational model of cardiac electromechanics (mathematical model of cellular electromechanics embedded in a simple geometric model of the cardiac left ventricle)
I
Intervention
Inclusion of cellular electrical heterogeneity (transmural heterogeneity of action potential duration)
C
Comparator
Electrically homogeneous cell model
O
Outcome
Fibre length transients and myocardial mechanics (peak tensions and fibre shortening)surrogate

A computational model demonstrates that transmural heterogeneity of action potential duration significantly reduces sarcomere length transmural dispersion during repolarization.

Cite This Study

Nickerson et al. (2005) studied this question.

synapsesocial.com/papers/6a1be653ea84844e355f261ahttps://doi.org/10.1016/j.eupc.2005.04.009
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Quantitative Reconstruction of Cardiac Electromechanics in Human Myocardium:2003 · 38 citations
  2. 2Mechanisms of transmurally varying myocyte electromechanics in an integrated computational model2008 · 47 citations
  3. 3Bioelectrical effects of mechanical feedbacks in a strongly coupled cardiac electro-mechanical model2015 · 34 citations
  4. 4Computationally efficient model of myocardial electromechanics for multiscale simulations2021 · 6 citations
  5. 5Effect of fibre orientation and bulk modulus on the electromechanical modelling of human ventricles2020 · 9 citations