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June 10, 1989BMJOpen Access

Relation between mortality and treated blood pressure in elderly patients with hypertension: report of the European Working Party on High Blood Pressure in the Elderly.

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Why the study?

Does active antihypertensive treatment alter the relationship between treated blood pressure and mortality in elderly patients with hypertension?

Population

691 elderly patients with hypertension, mean age 71.5 years, 70% women, baseline blood pressure 182/101 mm…

Comparison

Active antihypertensive treatment vs Placebo

Design

RCT, Randomised, double blind

Authors

JSJan A. StaessenCBCJ BulpittDCD Clément

Discussion

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Overview

Supports caution against very low achieved BPs in elderly hypertensives; extends J-curve evidence from active-treatment arms.

Structured PICO

Does active antihypertensive treatment alter the relationship between treated blood pressure and mortality in elderly patients with hypertension?

P
Population
691 elderly patients with hypertension (339 placebo, 352 active treatment), mean age 71.5 years, 70% women, baseline blood pressure 182/101 mm Hg, 35% with cardiovascular complications.
I
Intervention
Active antihypertensive treatment
C
Comparator
Placebo
O
Outcome
Total mortalityhard clinical

In elderly hypertensive patients, mortality has a U-shaped or inverse relationship with treated blood pressure, suggesting that the lowest achieved blood pressures may be associated with increased mortality and deteriorating general health.

Cite This Study

Staessen et al. (1989) studied this question.

synapsesocial.com/papers/6a1e6ea409554abc3868cf3dhttps://doi.org/10.1136/bmj.298.6687.1552
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1On-Treatment Diastolic Blood Pressure and Prognosis in Systolic Hypertension2007 · 151 citations
  2. 2Relation between treated blood pressure and death from ischaemic heart disease at different ages: a report from the Department of Health Hypertension Care Computing Project1992 · 8 citations
  3. 3Relation between blood pressure and stroke mortality.1992 · 51 citations
  4. 4Treated blood pressure, rather than pretreatment, predicts survival in hypertensive patients A report from the DHSS Hypertension Care Computing Project (DHCCP)1988 · 18 citations
  5. 5Optimal blood pressure control in treated hypertensive patients. Report from the Department of Health Hypertension Care Computing Project (DHCCP).1994 · 27 citations