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November 1, 1992Hypertension

The age-adjusted risk of stroke death increased by 1% for every 1 mm Hg increase in untreated systolic blood pressure (relative hazard rate 1.014 [95% CI, 1.007, 1.021] in men and 1.009 [1.003, 1.016] in women).

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Why the study?

Does blood pressure level correlate with stroke mortality in hypertensive patients?

Population

10,186 hypertensive patients

Design

Cohort

Follow-up

average of 9 years

Authors

APAndrew PalmerCBChristopher J. BulpittAFA. E. Fletcher

Discussion

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Overview

Linear SBP-stroke mortality link in untreated hypertension supports risk stratification; extends observational data but leaves optimal targets open.

Structured PICO

Does blood pressure level correlate with stroke mortality in hypertensive patients?

P
Population
10,186 hypertensive patients
O
Outcome
Stroke mortalityhard clinical

Stroke mortality increases linearly with both treated and untreated systolic and diastolic blood pressure in hypertensive patients, with no clear evidence of a J-shaped curve in men.

Cite This Study

Palmer et al. (1992) studied this question.

synapsesocial.com/papers/6a7e5a059e80099357991056https://doi.org/10.1161/01.hyp.20.5.601
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Relation between treated blood pressure and death from ischaemic heart disease at different ages: a report from the Department of Health Hypertension Care Computing Project1992 · 8 citations
  2. 2Optimal blood pressure control in treated hypertensive patients. Report from the Department of Health Hypertension Care Computing Project (DHCCP).1994 · 27 citations
  3. 3Risk of fatal stroke according to blood pressure level: an 18-year follow-up of the Oslo Study1995 · 15 citations
  4. 4Association Between Blood Pressure Level and the Risk of Myocardial Infarction, Stroke, and Total Mortality2001 · 430 citations
  5. 5Relation between mortality and treated blood pressure in elderly patients with hypertension: report of the European Working Party on High Blood Pressure in the Elderly.1989 · 231 citations