Key result
The positive relation between treated diastolic blood pressure and IHD mortality decreased with age, while the relative hazard rate for systolic blood pressure remained positive (1.008-1.021).
Why the study?
Does treated blood pressure level correlate with ischaemic heart disease mortality differently across age groups in hypertensive patients?
Cohort (n=6,216)
Yes
Does treated blood pressure level correlate with ischaemic heart disease mortality differently across age groups in hypertensive patients?
The positive relationship between treated diastolic blood pressure and ischemic heart disease mortality decreases with age, whereas the relationship with systolic blood pressure persists in older patients.
Answers are grounded in this paper and cite their sources.
Treated diastolic BP–IHD mortality link weakens with age while systolic persists; leaves open age-specific targets in hypertension.
OBJECTIVE: To determine the relation between mortality from ischaemic heart disease (IHD) and treated blood pressure at different ages. DESIGN: Prospectively, 6216 patients were studied for a mean of 107 months. SETTING: Of the total patients, 95% were followed in five hospital-based hypertension clinics and the remainder in four group general practices. PATIENTS: Respectively, 2250 and 2126 hypertensive men and women aged < 60 years and 822 and 1018 aged > or = 60 years. MAIN OUTCOME MEASURES: Mortality (any mention on the death certificate) from IHD. RESULTS: Four hundred and sixty-seven patients died with IHD mentioned on the death certificate. The relation between both diastolic blood pressure (DBP) and systolic blood pressure (SBP) during the first 3-12 months of treatment and subsequent IHD mortality was examined. Under the age of 60 years the relative hazard rate (RHR) for death from IHD tended to increase with DBP in both men and women. Above the age of 60 years there was no important or significant relation between IHD mortality and treated DBP. For SBP there was no reduction in the positive relation between IHD mortality and blood pressure in the older age groups. The RHR for SBP ranged between 1.008 and 1.021 in men and women over and under the age of 60 years. CONCLUSIONS: The positive relation between DBP and IHD mortality decreased with increasing age and, in women aged > or = 60 years, even inverted, partly explaining the negative relation reported between DBP and total mortality in the very old.
No takes yet. Share an insight, caveat, or question.
Bulpitt et al. (1992) conducted a cohort in Hypertension (n=6,216). Treated blood pressure vs. Lower treated blood pressure was evaluated on Mortality from ischaemic heart disease (RHR 1.008-1.021). The positive relation between treated diastolic blood pressure and IHD mortality decreased with age, while the relative hazard rate for systolic blood pressure remained positive (1.008-1.021).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: